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Distinct physiologic and neuronal responses to decreased leptin and mild hyperleptinemia

Endocrinology 140(11): 4923-4931

Distinct physiologic and neuronal responses to decreased leptin and mild hyperleptinemia

Leptin acts on specific populations of hypothalamic neurons to regulate feeding behaviour, energy expenditure, and neuroendocrine function. It is known, however, whether the same neural circuits mediate leptin action across its full biologic dose-response curve, which extends over a broad range, from low levels seen during starvation to high levels characteristic of obesity.

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Accession: 003408794

PMID: 10537115

DOI: 10.1210/endo.140.11.7105

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