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Distribution and origin of tetrodotoxin


, : Distribution and origin of tetrodotoxin. Journal of Toxicology, Toxin Reviews 20(1): 11-33

Among the marine toxins relevant for human intoxication, tetrodotoxin (TTX) has been known as one of the most prejudicial. Puffer fish were originally thought to be the only animal from which TTX could be isolated.

Accession: 003408947

DOI: 10.1081/TXR-100103081

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Related references

Yasumoto, T.; Nagai, H.; Yasumura, D.; Michishita, T.; Endo, A.; Yotsu, M.; Kotaki, Y., 1986: Interspecies distribution and possible origin of tetrodotoxin. Annals of the New York Academy of Sciences 479: 44-51

Yasumoto T.; Yasumura D.; Nagai H.; Michishita T.; Yotsu M., 1985: Distribution and possible origin of tetrodotoxin in marine animals. Japanese Journal of Medical Science & Biology 38(5-6): 259

Yasumoto, T.; Yotsu, M.; Endo, A.; Murata, M.; Naoki, H., 1989: Interspecies distribution and biogenetic origin of tetrodotoxin and its derivatives. Pure and Applied Chemistry, 613: 505-508

Lago, J.; Rodríguez, L.P.; Blanco, Lía.; Vieites, J.Manuel.; Cabado, A.G., 2016: Tetrodotoxin, an Extremely Potent Marine Neurotoxin: Distribution, Toxicity, Origin and Therapeutical Uses. Tetrodotoxin (TTX) is a potent neurotoxin responsible for many human intoxications and fatalities each year. The origin of TTX is unknown, but in the pufferfish, it seems to be produced by endosymbiotic bacteria that often seem to be passed down t...

Tao, J.; Wei, W.J.; Nan, L.; Lei, L.H.; Hui, H.C.; Fen, G.X.; Jun, L.Y.; Jing, Z.; Rong, J., 2011: Development of competitive indirect ELISA for the detection of tetrodotoxin and a survey of the distribution of tetrodotoxin in the tissues of wild puffer fish in the waters of south-east China. A monoclonal antibody against tetrodotoxin (TTX) was produced from the hybridoma cell line T6D9, which was established by the fusion of Sp2/0 myeloma cells with spleen cells isolated from a Balb/c mouse immunized with the TTX-keyhole limpet hemocy...

Yasumoto T.; Yotsu M.; Khora S.S., 1990: Biogenetic origin and metabolic pathways of tetrodotoxin. Abstracts of Papers American Chemical Society 200(1-2): AGFD 78

Jal, S.; Khora, S.S., 2016: An overview on the origin and production of tetrodotoxin, a potent neurotoxin. Tetrodotoxin (TTX) is a deadly neurotoxin which selectively inhibits Na(+) activation mechanism of nerve impulse, without affecting the permeability of K(+) ions. Because of this sodium channel blocking action, it is majorly being studied for biom...

Noguchi T.; Arakawa O.; Hashimoto K., 1989: Tetrodotoxin with special reference to its origin and the mechanism involved in toxification of puffers. Journal of the Food Hygienic Society of Japan 30(4): 281-288

Lehman, E.M.; Brodie, E.D.; Brodie, E.D., 2004: No evidence for an endosymbiotic bacterial origin of tetrodotoxin in the newt Taricha granulosa. Tetrodotoxin (TTX) is a potent neurotoxin which is known to occur in numerous taxa, including newts. The origin of TTX is unknown, but production by symbiotic bacteria is suspected for some groups. Using PCR primers that specifically amplify 16S r...

Pavelka, L.A.; Kim, Y.H.; Mosher, H.S., 1977: Tetrodotoxin and tetrodotoxin-like compounds from the eggs of the Costa Rican frog, Atelopus chiriquiensis. Toxicon 15(2): 135-139