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Effect of Ocimum sanctum Linn on peptic ulcers and gastric mucosal offensive and defensive factors






Biomedicine 20(4): 260-267

Effect of Ocimum sanctum Linn on peptic ulcers and gastric mucosal offensive and defensive factors

Ocimum sanctum Linn is a commonly mentioned plant in a number of Ayurvedic texts like Caraka samhita, Susrutha and Cakaradutta. Its multifaceted activities has been widely reported. The present study incorporates an extensive study on juice of fresh leaves of O. sanctum on gastric ulceration and on various offensive factors like acid and pepsin secretion and defensive mucosal factors like mucin secretion, mucosal cell shedding and glycoproteins.


Accession: 003414315



Related references

Goel, R.K.; Sairam, K.; Dorababu, M.; Prabha, T.; Rao, C.V., 2005: Effect of standardized extract of Ocimum sanctum Linn. on gastric mucosal offensive and defensive factors. The standardized methanolic extract of leaves of O. sanctum (OSE; eugenol content 5%) given in doses of 50-200 mg/kg, orally, twice daily for five days showed dose-dependent ulcer protective effect against cold restraint stress induced gastric ulc...

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Joshi, M.C.; Dorababu, M.; Prabha, T.; Kumar, M.M.; Goel, R.K., 2004: Effects of Pterocarpus marsupium on NIDDM-induced rat gastric ulceration and mucosal offensive and defensive factors. Objective: To evaluate the vulnerability of gastric mucosa to ulceration in non-insulin-dependent diabetes mellitus (NIDDM) rats visa-vis the protective effects of the methanolic extract of Pterocarpus marsupium heartwood (PMS, an antidiabetic her...

Chopra, R.N.; Roy, D.N.; Ghosh, S.M., 1941: The insecticidal and larvicidal Action of the Essential Oils of Ocimum basilicum (Linn.) and Ocimum sanctum (Linn.). In continued investigations on the effectiveness of Indian plants reputed to have insecticidal properties, the essential oils from leaves of Ocimum basilicum and two varieties of O. sanctum were shown to have some toxicity for adults of Aedes aegy...

Mandal, S.; Das, D.N.; De, K.; Ray, K.; Roy, G.; Chaudhuri, S.B.; Sahana, C.C.; Chowdhuri, M.K., 1993: Ocimum sanctum Linn--a study on gastric ulceration and gastric secretion in rats. The antiulcerogenic property of Ocimum sanctum Linn (Tulsi) was studied in pyloric ligated and pyloric ligated & aspirin treated rats. The extract of OSL reduced the ulcer index, free & total acidity on acute and chronic administration. Se...