Effect of vitamin E supplementation on antibody levels against malondialdehyde modified LDL in hyperlipidemic hamsters
de Oliveira, F.G.; Rossi, C.L.; de Oliveira, M.G.; Saad, M.J.; Velloso, L.A.
Cardiovascular Research 47(3): 567-573
ISSN/ISBN: 0008-6363 PMID: 10963729 DOI: 10.1016/s0008-6363(00)00121-8
The aim of this work was to investigate the effect of vitamin E (VE) supplementation on the formation of autoantibodies against oxidized low density lipoproteins (LDL) in a hyperlipidaemic animal model. 34 male hamsters (Mesocricetus auratus), (4 weeks old) were divided into 3 groups: Group A (n=9) was fed with standard rodent chow; group B (n=13) was fed with a standard rodent chow + 2% cholesterol and 10% butter and group C (n=12) was fed with the same diet plus 0.2% (w/w) VE. Blood samples were collected by intracardiac puncture and antibody levels were determined in each hamster at 4 weeks of age and after 20 weeks of experimental diet.