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Extracellular signal-related kinase (ERK) and p38 mitogen-activated protein (MAP) kinases differentially regulate the lipopolysaccharide-mediated induction of inducible nitric oxide synthase and IL-12 in macrophages: Leishmania phosphoglycans subvert macrophage IL-12 production by targeting ERK MAP kinase



Extracellular signal-related kinase (ERK) and p38 mitogen-activated protein (MAP) kinases differentially regulate the lipopolysaccharide-mediated induction of inducible nitric oxide synthase and IL-12 in macrophages: Leishmania phosphoglycans subvert macrophage IL-12 production by targeting ERK MAP kinase



Journal of Immunology Baltimore 163(12): 6403-6412



Using cultured murine peritoneal macrophages, this study showed that the extracellular signal-related kinase (ERK) and p38 mitogen-activated protein (MAP) kinases play different roles in the regulation of lipopolysaccharide (LPS)-stimulated inducible nitric oxide (NO) synthase and interleukin (IL)-12 gene expression. LPS stimulated the simultaneous activation of all 3 classes of MAP kinases, namely ERK, c-jun N-terminal kinase, and p38, albeit with different activation kinetics.

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