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HLA-DR-promiscuous T cell epitopes from Plasmodium falciparum pre-erythrocytic-stage antigens restricted by multiple HLA class II alleles


HLA-DR-promiscuous T cell epitopes from Plasmodium falciparum pre-erythrocytic-stage antigens restricted by multiple HLA class II alleles



Journal of Immunology 165(2): 1123-1137



ISSN/ISBN: 0022-1767

PMID: 10878392

DOI: 10.4049/jimmunol.165.2.1123

The antigenicity of 17 CD8+ T cell epitopes from 5 Plasmodium falciparum antigens that are restricted by multiple common HLA class I alleles was previously established. The identification of 11 peptides from the same antigens, circumsporozoite protein, sporozoite surface protein 2, exported protein-1 and liver-stage antigen-1, that bind between at least 5 and up to 11 different HLA-DR molecules representative of the most common HLA-DR antigens worldwide is now reported.

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Accession: 003460844

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