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Insulin and raclopride combine to decrease short-term intake of sucrose solutions



Insulin and raclopride combine to decrease short-term intake of sucrose solutions



Peptides 21(9): 1361-1367



We have previously reported that the hormone insulin can modulate synaptic function of dopamine neurons. To evaluate whether insulin can alter performance of a task which is dependent on intact dopaminergic signaling, we tested rats in a five minute lick rate task, with a range of concentrations of sucrose or oil solutions. Rats received either ip (t -15 min.) saline or the D2 receptor antagonist raclopride (50 micro g/kg), and intraventricular (t -4 h) saline or insulin (5 mU).

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Accession: 003480028

Download citation: RISBibTeXText

PMID: 11072123

DOI: 10.1016/s0196-9781(00)00279-5


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