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Insulin-like growth factor I is essential for terminal end bud formation and ductal morphogenesis during mammary development



Insulin-like growth factor I is essential for terminal end bud formation and ductal morphogenesis during mammary development



Endocrinology 140(11): 5075-5081



Evidence was obtained that, even when somatotropin is present, no mammary development is possible unless IGF-I is present. IGF-I(-/-) null female mice had significantly less mammary development than age-matched wild-type controls (P<0.006) using several criteria, including the number of terminal end buds (1.3 vs. 7.3), percentage of the fat pad occupied by glandular elements (6.5 vs. 100), and number of ducts (15 vs. too numerous to count).

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Accession: 003480067

Download citation: RISBibTeXText

PMID: 10537134

DOI: 10.1210/endo.140.11.7095


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