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Insulin-like growth factor I mediates high-fat diet-induced adipogenesis in Osborne-Mendel rats



Insulin-like growth factor I mediates high-fat diet-induced adipogenesis in Osborne-Mendel rats



American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 278(3): R654-R662



To determine if high-fat (HF) diet-induced changes in adipose tissue cellularity are associated with the presence of paracrine growth factor(s) that alter preadipocyte proliferation, Osborne-Mendel rats were fed either a HF (76% energy) or a low-fat (LF, 12% energy) diet for 85 days. HF-fed rats had greater (P < 0.05) fat pad size, total fat cell number, number of small (30-70 mm) and large (80-140 mm) adipocytes, and percentage of 100- to 140-mm adipocytes compared with LF-fed rats. Preadipocytes in primary cell culture treated with inguinal adipose tissue conditioned medium (ATCM) prepared from HF-fed rats had greater (P < 0.05) proliferation compared with cultures treated with ATCM from LF-fed rats. Proliferative capacity of ATCM prepared from HF-fed rats was attenuated after the stripping of the medium of insulin-like growth factor I using an immunomagnetic bead separation system. These data are consistent with the concept that insulin-like growth factor I is involved in the paracrine regulation of adipogenesis. Reprinted by permission of the publisher.

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Accession: 003480068

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PMID: 10712285


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