+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Insulin-like growth factors and bone mineral density in African American and White girls

Insulin-like growth factors and bone mineral density in African American and White girls

Journal of Pediatrics 137(6): 826-832

A study was conducted to examine the hypothesis that differences in insulin-like growth factors (IGFs) may be an important determinant of racial differences in bone mineral density (BMD) during childhood [Maryland, USA; date not given]. 59 African American and 59 white girls, matched for age, body mass index, socioeconomic status and pubertal stage, participated in the study. African-American girls had greater total BMD, insulin-like growth factor 1 and free IGF-1 levels than white girsl, independent of pubertal stage. IGF was positively correlated with IGF2 in white girls (P=0.012), but negatively correlated with IGF2 in African Americans (P=0.15). A positive correlation was observed in IGF and free IGF-1 with BMD/BMC. It is concluded that IGF-1 and free IGF-1 are greater in African American than in white girls and may contribute to the greater BMD of African Americans.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 003480082

Download citation: RISBibTeXText

PMID: 11113840

DOI: 10.1067/mpd.2000.109151

Related references

Differences between African American and white girls in the insulin-like growth factor-I and the binding proteins: importance of insulin resistance and hyperinsulinemia. Journal of Pediatrics 135(3): 270-271, 1999

Serum concentrations of insulin, insulin-like growth factor-I, and insulin-like growth factor binding proteins are different between white and African American girls. Journal of Pediatrics 135(3): 296-300, 1999

Relationship between abdominal fat and bone mineral density in white and African American adults. Bone 50(2): 576-579, 2012

Higher Serum Insulin Concentrations Positively Influence the Bone Mineral Density in African American Adolescents. British Journal of Medicine and Medical Research 3(4): 1050-1061, 2014

Differential effect of obesity on bone mineral density in White, Hispanic and African American women: a cross sectional study. Nutrition & Metabolism 2(1): 9-9, 2005

Vitamin D receptor gene predicts volumetric bone mineral density and serum insulin-like growth factor-I in prepubertal girls. Journal of Bone & Mineral Research 14(SUPPL 1): S454, Sept, 1999

Black girls have higher plasma insulin levels than white girls at ages 9- and 10-years, but insulin associations with CHD risk factors are stronger in white girls. Circulation 98(17 SUPPL ): I374-I375, Oct 27, 1998

Relationship between serum level of growth differentiation factors 8, 11 and bone mineral density in girls with anorexia nervosa. Clinical Endocrinology 2018, 2018

Differential distribution of insulin-like growth factors and their binding proteins within bone: relationship to bone mineral density. Journal of Bone and Mineral Research 9(11): 1803-1811, 1994

Is there an association between skeletal muscle mass and bone mineral density among African-American, Asian-American, and European-American women?. Acta Diabetologica 40 Suppl 1: S309-S313, 2003

Bone matrix insulin-like growth factor (IGF)-I, IGF-II and transforming growth factor (TGF)-beta1 levels in men and postmenopausal women with osteoporosis: lack of association with circulating growth factors and bone mineral density. Revista Medico-Chirurgicala a Societatii de Medici Si Naturalisti Din Iasi 108(2): 281-286, 2005

Effects of exercise training on bone remodeling, insulin-like growth factors, and bone mineral density in postmenopausal women with and without hormone replacement therapy. Calcified Tissue International 72(4): 478-484, 2003

Growth differences by age of menarche in African American and White girls. Nursing Research 58(6): 382-390, 2009

The roles of insulin sensitivity, insulin-like growth factor I (IGF-I), and IGF-binding protein-1 and -3 in the hyperandrogenism of African-American and Caribbean Hispanic girls with premature adrenarche. Journal of Clinical Endocrinology and Metabolism 84(6): 2037-2042, 1999

Prediction of changes in total and regional bone mineral density from changes in osteocalcin, deoxypyridinoline-crosslinks, and insulin-like growth factors. Medicine & Science in Sports & Exercise 32(5 Suppl ): S269, 2000