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Insulin-like growth factors and bone mineral density in African American and White girls



Insulin-like growth factors and bone mineral density in African American and White girls



Journal of Pediatrics 137(6): 826-832



A study was conducted to examine the hypothesis that differences in insulin-like growth factors (IGFs) may be an important determinant of racial differences in bone mineral density (BMD) during childhood [Maryland, USA; date not given]. 59 African American and 59 white girls, matched for age, body mass index, socioeconomic status and pubertal stage, participated in the study. African-American girls had greater total BMD, insulin-like growth factor 1 and free IGF-1 levels than white girsl, independent of pubertal stage. IGF was positively correlated with IGF2 in white girls (P=0.012), but negatively correlated with IGF2 in African Americans (P=0.15). A positive correlation was observed in IGF and free IGF-1 with BMD/BMC. It is concluded that IGF-1 and free IGF-1 are greater in African American than in white girls and may contribute to the greater BMD of African Americans.

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Accession: 003480082

Download citation: RISBibTeXText

PMID: 11113840

DOI: 10.1067/mpd.2000.109151


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