+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Integration of the metabolic pathways of steroids, carotenoids, and retinoids



Integration of the metabolic pathways of steroids, carotenoids, and retinoids



Critical Reviews in Biochemistry and Molecular Biology 34(6): 405-410



The biosynthetic pathway for the formation of isoprenoid compounds in plants is similar to the pathway of sterol biosynthesis in animals and yeast. In plants, isoprenoids are synthesized from acetyl-CoA via mevalonate and isopentyl pyrophosphate to long-chain prenyl pyrophosphates. These compounds may then be metabolized to form various isoprenoid compounds. The bovine corpus luteum, which utilizes the Porter-Lincon pathway, has been shown to metabolize acetate to steroids and beta -carotene. For example, farnesyl pyrophosphate is an intermediate in the production of steroids and beta -carotene. The synthesis of carotenoids continues with the condensation of two molecules of geranylgeranyl pyrophosphate to phytoene (C40 hydrocarbon), phytofluene, and eventually to beta -carotene. beta -Carotene can then be metabolized to retinol. Retinol is important for the synthesis of cholesterol and the metabolism of various steroids, such as pregnenolone and progesterone. The action of vitamin A on progesterone metabolism is important for embryonic development.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 003480646

Download citation: RISBibTeXText

PMID: 10711785

DOI: 10.1080/10409239991209372


Related references

Isolation of three new carotenoids and proposed metabolic pathways of carotenoids in hen's egg yolk. Comparative Biochemistry and Physiology B 84(4): 477-482, 1986

Pharmacokinetic and metabolic pathways of systemically applied retinoids. Dermatologica 157 Suppl 1: 5-10, 1978

Reductive metabolic pathways of carotenoids in fish 3s 3's astaxanthin to tunaxanthin a b and c. Comparative Biochemistry and Physiology B 80(4): 779-790, 1985

Progress on molecular breeding and metabolic engineering of biosynthesis pathways of C(30), C(35), C(40), C(45), C(50) carotenoids. Biotechnology Advances 25(3): 211-222, 2007

Metabolic pathways of carotenoids in chum salmon Oncorhynchus keta during spawning migration. Comparative Biochemistry and Physiology. B, Comparative Biochemistry 87(2): 411-416, 1987

Novel reductive metabolic pathways of 4-oxo--end group in carotenoids of the spindle shell Fusinus perplexus. Comparative Biochemistry and Physiology B Comparative Biochemistry, 814: 905-908, 1985

Novel reductive metabolic pathways of 4 oxo beta end group in carotenoids of the spindle shell fusinus perplexus. Comparative Biochemistry & Physiology B 81(4): 905-908, 1985

Metabolic pathways of steroids in insects. Proceedings of the Royal Society of London. Series B, Biological Sciences 180(1059): 203-221, 1972

Carotenoids of shellfishes x. reductive metabolic pathways of echinenone and fritschiellaxanthin in the spindle shell fusinus perplexus. Comparative Biochemistry and Physiology B 92(1): 189-194, 1989

The integration of metabolic pathways. Annual Review of Plant Physiology 14(1): 19-42, 1963

Non-traditional metabolic pathways of adrenal steroids. Reviews in Endocrine and Metabolic Disorders 10(1): 27-32, 2008

The co ordination and integration of metabolic pathways. Palmer, J M (Ed ) Society For Experimental Biology Seminar Series, Vol 20 The Physiology And Biochemistry Of Plant Respiration; Meeting, 1980 Ix+195p Cambridge University Press: New York, N Y , Usa; Cambridge, England Illus 159-170, 1984, 1985

The co-ordination and integration of metabolic pathways. Seminar series Society for Experimental Biology0(20): 159-170, 1984

The metabolic pathways for hormonal steroids appear to be reflected in the stereochemistry of DNA. Journal of Steroid Biochemistry and Molecular Biology 42(7): 659-670, 1992

Parallel Integration and Chromosomal Expansion of Metabolic Pathways. Acs Synthetic Biology 7(11): 2566-2576, 2018