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Internalization of Leishmania mexicana complex amastigotes via the Fc receptor is required to sustain infection in murine cutaneous leishmaniasis



Internalization of Leishmania mexicana complex amastigotes via the Fc receptor is required to sustain infection in murine cutaneous leishmaniasis



Journal of Experimental Medicine 191(6): 1063-1068



It was shown that maintenance of Leishmania infections with Leishmania mexicana complex parasites (Leishmania amazonensis and Leishmania pifanoi) is impaired in the absence of circulating antibody. Mice genetically altered to contain no circulating antibody, with and without functional B cells, were used. The experimental design ruled out a critical role for B cell antigen presentation in Leishmania pathogenesis.

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Accession: 003481737

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PMID: 10727468

DOI: 10.1084/jem.191.6.1063


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