+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Monoterpenes inhibit cell growth, cell cycle progression, and cyclin D1 gene expression in human breast cancer cell lines



Monoterpenes inhibit cell growth, cell cycle progression, and cyclin D1 gene expression in human breast cancer cell lines



Nutrition and Cancer 32(1): 1-7



Monoterpenes are found in the essential oils of many commonly consumed fruits and vegetables. These compounds have been shown to exert chemopreventive and chemotherapeutic activities in mammary tumor models and represent a new class of breast cancer therapeutic agents. In this study, we investigated the effects of limonene and limonene-related monoterpenes, perillyl alcohol and perillic acid, on cell growth, cell cycle progression, and expression of cyclin D1 cell cycle-regulatory gene in T-47D, MCF-7, and MDA-MB-231 breast cancer cell lines. Our results revealed that limonene-related monoterpenes caused a dose-dependent inhibition of cell proliferation. Of the three monoterpenes tested, perillyl alcohol was the most potent and limonene was the least potent inhibitor of cell growth. The enantiomeric composition of limonene and perillyl alcohol did not interfere with their effect on cell growth. Sensitivity of breast cancer cell lines to monoterpenes was in the following order: T-47D > MCF-7 > MDA-MB-231. Growth inhibition induced by perillyl alcohol and perillic acid was associated with a fall in the proportion of cells in the S phase and an accumulation of cells in the G1 phase of the cell cycle. Finally, we showed that the effects of limonene-related monoterpenes on cell proliferation and cell cycle progression were preceded by a decrease in cyclin D1 mRNA levels.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 003503740

Download citation: RISBibTeXText

PMID: 9824849

DOI: 10.1080/01635589809514708


Related references

Growth factor, steroid, and steroid antagonist regulation of cyclin gene expression associated with changes in T-47D human breast cancer cell cycle progression. Molecular and Cellular Biology 13(6): 3577-3587, 1993

Antiestrogen regulation of cell cycle progression and cyclin D1 gene expression in MCF-7 human breast cancer cells. Breast Cancer Research & Treatment. 31(1): 95-105, 1994

Effects of olomoucine, a selective inhibitor of cyclin-dependent kinases, on cell cycle progression in human cancer cell lines. Anti-Cancer Drugs 8(6): 623-631, 1997

Effects of olomoucjne, a selective inhibitor of cyclin-dependent kinases, on cell cycle progression in human cancer cell lines. Anti-Cancer Drugs 8(6): 623-631, 1997

Flow cytometry study of human cyclin B1 and cyclin E expression in leukemic cell lines: cell cycle kinetics and cell localization. Experimental Cell Research 247(1): 208-219, 1999

The effect of retinoic acids on the cell cycle progression and the expression of cyclin D1 in human breast cancer cells. Proceedings of the American Association for Cancer Research Annual Meeting 37: 502, 1996

Lin-28 homologue A (LIN28A) promotes cell cycle progression via regulation of cyclin-dependent kinase 2 (CDK2), cyclin D1 (CCND1), and cell division cycle 25 homolog A (CDC25A) expression in cancer. Journal of Biological Chemistry 287(21): 17386-17397, 2012

Chenopodium album prevents progression of cell growth and enhances cell toxicity in human breast cancer cell lines. Oxidative Medicine and Cellular Longevity 2(3): 160-165, 2011

Anti-transforming growth factor (TGF)-beta antibodies inhibit breast cancer cell tumorigenicity and increase mouse spleen natural killer cell activity. Implications for a possible role of tumor cell/host TGF-beta interactions in human breast cancer progression. Journal of Clinical Investigation 92(6): 2569-2576, 1993

The effects of a growth-inhibiting tripeptide, acetylGlu-Ser-GlyNH2 (Ac-ESG), on gene expression and cell cycle progression of two lymphoma cell lines. Anticancer Research 23(4): 3159-3165, 2003

Continuous exposition of human breast and bladder cancer cell lines to bromodeoxyuridine differentially affects cell cycle progression. Cytometry 59A(1): 80, 2004

Cyclin D1 protein oscillates and is essential for cell cycle progression in human tumour cell lines. Oncogene 9(3): 707-718, 1994

Exposure to continuous bromodeoxyuridine (BrdU) differentially affects cell cycle progression of human breast and bladder cancer cell lines. Cell Proliferation 37(2): 195-206, 2004

Expression of pRB, cyclin/cyclin-dependent kinases and E2F1/DP-1 in human tumor lines in cell culture and in xenograft tissues and response to cell cycle agents. Cancer ChemoTherapy and Pharmacology 46(4): 293-304, 2000

Effects of acyclic retinoid on growth, cell cycle control, the EGFR signaling pathway, and gene expression in human squamous cell carcinoma cell lines. Proceedings of the American Association for Cancer Research Annual Meeting 44: 1090, 2003