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Murine CD4+ T lymphocyte subsets and host defense against Pneumocystis carinii



Murine CD4+ T lymphocyte subsets and host defense against Pneumocystis carinii



Journal of Infectious Diseases 181(6): 2011-2017



The recruitment of specific subsets of CD4+ T lymphocytes to the lungs in response to P. carinii was investigated. For mice inoculated with P. carinii, an ELISPOT assay was used to calculate the numbers of lymph node and lung tissue CD4+ cells that secreted interferon (IFN)- gamma (Th1 cytokine) and interleukin (IL)-4 (Th2 cytokine) after concanavalin A stimulation. An ELISA was used to assay culture supernatants for cytokine concentrations.

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Accession: 003505480

Download citation: RISBibTeXText

PMID: 10837183

DOI: 10.1086/315487


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