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Occurrence of severe destructive lyme arthritis in hamsters vaccinated with outer surface protein A and challenged with Borrelia burgdorferi



Occurrence of severe destructive lyme arthritis in hamsters vaccinated with outer surface protein A and challenged with Borrelia burgdorferi



Infection and Immunity 68(2): 658-663



Direct evidence that a major surface protein, outer surface protein A (OspA), can induce arthritis is provided. Hamsters were vaccinated with 30, 60 or 120 micro g of recombinant OspA (rOspA) in aluminium hydroxide and challenged with B. burgdorferi s.s. isolate 297 or C-1-11. Swelling of the hind paws was detected in 100%, 100% and 50% of hamsters vaccinated with 30, 60 or 120 micro g of rOspA, respectively.

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Accession: 003513856

Download citation: RISBibTeXText

PMID: 10639430

DOI: 10.1128/IAI.68.2.658-663.2000


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