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Ochratoxin A induces JNK activation and apoptosis in MDCK-C7 cells at nanomolar concentrations



Ochratoxin A induces JNK activation and apoptosis in MDCK-C7 cells at nanomolar concentrations



Journal of Pharmacology and Experimental Therapeutics 293(3): 837-844



Ochratoxin A (OTA) is a ubiquitous fungal metabolite with nephritogenic, carcinogenic, and teratogenic action. Epidemiological studies indicate that OTA may be involved in the pathogenesis of different forms of human nephropathies. Previously we have shown that OTA activates extracellular signal-regulated kinases 1 and 2, members of the mitogen-activated protein kinases (MAPK) family, in the C7-clone but not in the C11-clone of renal epithelial Madin-Darby canine kidney (MDCK) cells.

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Accession: 003513971

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PMID: 10869383


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