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Oral immunogenicity of the plant derived spike protein from swine-transmissible gastroenteritis coronavirus

Oral immunogenicity of the plant derived spike protein from swine-transmissible gastroenteritis coronavirus

Archives of Virology 145(8): 1725-1732

Transgenic plants represent an inexpensive alternative to classical fermentation systems for production of recombinant subunit vaccines. Transgenic potato plants were created that express the N-terminal domain of the glycoprotein S (N-gS) from transmissible gastroenteritis coronavirus (TGEV), containing the major antigenic sites of the protein. Extracts from potato tubers expressing N-gS were inoculated intraperitoneally to mice, and the vaccinated mice developed serum IgG specific for TGEV.

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Accession: 003516141

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PMID: 11003480

DOI: 10.1007/s007050070087

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