Protective role of lung surfactant protein D in a murine model of invasive pulmonary aspergillosis
Madan, T.; Kishore, U.; Singh, M.; Strong, P.; Hussain, E.M.; Reid, K.B.; Sarma, P.U.
Infection and Immunity 69(4): 2728-2731
ISSN/ISBN: 0019-9567 PMID: 11254642 DOI: 10.1128/iai.69.4.2728-2731.2001
The protective effects of intranasal administration of amphotericin B (AmB), human SP-A, SP-D and a 60-kDa fragment of SP-D (rSP-D) were examined in a murine model of invasive pulmonary aspergillosis (IPA). The untreated group of IPA mice showed no survival at 7 days postinfection. Treatment with AmB, SP-D, and rSP-D increased the survival rate to 80, 60, and 80%, respectively, suggesting that SP-D (and rSP-D) can protect immunosuppressed mice from an otherwise fatal challenge with Aspergillus fumigatus conidia.