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Sensitivity of specific immune function tests to acute nutrient deprivation as indicators of nutritional status in a feline model



Sensitivity of specific immune function tests to acute nutrient deprivation as indicators of nutritional status in a feline model



Nutrition Research 20(1): 79-89



The sensitivity of monocyte phagocytic activity, major histocompatibility complex (MHC) class II expression, and fibronectin concentration were studied in 23 healthy cats during a 7-day fast followed by a 7-day refeeding period. Immune cell function tests, and body weight were determined on days 0, 4, 7, 11, and 14. Phagocytic activity, weight, lymphocyte number, white blood cell (WBC) number, MHC class II expression, and percent lymphocytes decreased (p<0.05) during the starvation period. Fibronectin concentration increased (p<0.05) by day 4 of starvation then decreased by day 7. During refeeding there was an increase (p<0.05) in MHC class II, fibronectin, weight, lymphocyte number, percent lymphocytes, and WBC number when compared to day 7. Macrophage phagocytic activity decreased (p<0.05) on day 11, followed by an increase on day 14. There was a positive correlation (p<0.05, r=0.3588) between monocyte number and MHC class II expression, and monocyte number and WBC number (p<0.05, r=0.3506). There was a positive correlation (p<0.05, r=0.2682) between weight change and phagocytic activity. In conclusion, MHC class II expression and phagocytosis were found to be reliable indicators of nutritional status during acute nutritional deprivation; however, fibronectin was not found to be a reliable indicator of nutritional status as it lacked consistency in its response to nutritional depletion and repletion.

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Accession: 003557339

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DOI: 10.1016/s0271-5317(99)00140-2



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