+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Structure-activity relationship of a neurite outgrowth-promoting substance purified from the brown alga, Sargassum macrocarpum, and its analogues on PC12D cells



Structure-activity relationship of a neurite outgrowth-promoting substance purified from the brown alga, Sargassum macrocarpum, and its analogues on PC12D cells



Journal of Applied Phycology 13(4): 349-357



The structure-activity relationship of a neurite outgrowth-promoting substance (designated as MC14) from the brown alga, Sargassum macrocarpum, was analysed. Eight synthetic carotenoids and 1,4-benzoquinone were used to determine the moiety of the MC14 molecule structurally responsible for the nerve growth factor (NGF)-mediated neurite outgrowth-promoting activity on PC12D cells. The bioassays showed that none of these carotenoids exhibited NGF-potentiating activity.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 003568792

Download citation: RISBibTeXText

DOI: 10.1023/a:1017540620106


Related references

Sargachromenol, a novel nerve growth factor-potentiating substance isolated from Sargassum macrocarpum, promotes neurite outgrowth and survival via distinct signaling pathways in PC12D cells. Neuroscience 132(3): 633-643, 2005

Nardosinone, the first enhancer of neurite outgrowth-promoting activity of staurosporine and dibutyryl cyclic AMP in PC12D cells. Brain Research. Developmental Brain Research 145(2): 177-183, 2003

Neurite outgrowth promoting activity of marine algae from Japan against rat adrenal medulla pheochromocytoma cell line, PC12D. Cytotechnology40(1-3):99, 2002

Novel effect of vitamin K1 and vitamin K2 on promoting nerve growth factor-mediated neurite outgrowth from PC12D cells. Neuroscience Letters 323(1): 9-12, 2002

Novel effect of vitamin K(1) (phylloquinone) and vitamin K(2) (menaquinone) on promoting nerve growth factor-mediated neurite outgrowth from PC12D cells. Neuroscience Letters 323(1): 9-12, 2002

Synthesis of verbenachalcone congeners and their biological assessment against activation of the NGF-mediated neurite outgrowth of PC12D cells' activity. Bioorganic and Medicinal Chemistry 14(8): 2753-2762, 2006

Age- and size-based morphological comparison between the brown alga Sargassum macrocarpum Heterokonta; Fucales from different depths at an exposed coast in northern Kyoto, Japan. Journal of Applied Phycology 25(6): 1815-1822, 2013

A human gene family of neurite outgrowth promoting proteins heparin binding neurite outgrowth promoting factor maps to 11p11 greater than 11p13. Cytogenetics & Cell Genetics 58(1-4): 1958, 1991

In vivo antiviral activity of an interferon beta production-promoting fraction from the marine brown alga, Sargassum hemiphyllum (Turner) C. Agardh. Botanica Marina 48(1): 84-86, 2005

Response of purified chick motoneurons to myotube conditioned medium: laminin is essential for the substratum-binding, neurite outgrowth-promoting activity. Neuroscience Letters 59(2): 183-189, 1985

Nardosinone, a novel enhancer of nerve growth factor in neurite outgrowth from PC12D cells. Neuroscience Letters 273(1): 53-56, 1999

NGF-dependent formation of ruffles in PC12D cells required a different pathway from that for neurite outgrowth. Neurochemistry International 51(2-4): 216-226, 2007

A human gene family of neurite outgrowth promoting proteins the gene for a heparin binding neurite outgrowth promoting factor maps to 7q22 greater than qter. Cytogenetics & Cell Genetics 58(1-4): 1920, 1991