+ Site Statistics
References:
52,654,530
Abstracts:
29,560,856
PMIDs:
28,072,755
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

The effect of acute restraint stress on regional brain neurotransmitter levels in stress-susceptible Pietrain pigs



The effect of acute restraint stress on regional brain neurotransmitter levels in stress-susceptible Pietrain pigs



Journal of Veterinary Medicine Series A 47(5): 257-269



Concentrations of noradrenaline (NA), adrenaline (A), dopamine (DA), 5-hydroxytryptamine (5-HT), the DA metabolites 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) and the main 5-HT metabolite 5-hydroxyindole-3-acetic acid (5-HIAA) were measured using HPLC in 16 brain areas of control and immobilized Pietrain pigs. The animals were immobilized for 15, 30 and 60 min in the prone position. Control pigs showed patterns of regional distribution of brain monoamines similar to those described for rats, dogs and Duroc pigs. However, the absolute values of NA and A in the hypothalamus and preoptic area were much higher than those in rats and dogs, but similar to those in Duroc pigs. The concentrations of dopamine and its metabolites DOPAC and HVA were highest in the caudate nucleus, the nucleus accumbens, the olfactory tubercle and the ventral tegmental area. The distributions of serotonin and its metabolite 5-HIAA were similar in all examined structures. DOPAC/DA and HVA/DA ratios were higher in the cornu ammonis, the hippocampus posterior and the raphe nuclei than in other structures, which suggests brain structure-related differences in dopamine turnover. The greatest decreases in NA and A content were observed in the hypothalamus, the preoptic area and the olfactory tuberculum during the first 30 min of immobilization stress. 5-HT turnover was increased in the raphe nuclei, while DA turnover was affected in the raphe nuclei, the septum, the substantia nigra and the olfactory tubercle. We suggest that acute immobilization stress caused differences in regional patterns of brain biogenic amines, thereby maintaining adequate transmitter levels during stress in stress-susceptible pigs.

(PDF emailed within 0-6 h: $19.90)

Accession: 003583508

Download citation: RISBibTeXText

PMID: 10932522

DOI: 10.1046/j.1439-0442.2000.00262.x


Related references

Regional brain neurotransmitter concentrations in stress-susceptible pigs. Journal of Animal Science 71(4): 968-974, 1993

Genetic differences in brain monoamines level in Pietrain and Duroc pigs exposed to acute restraint stress. Journal of Animal Breeding & Genetics 120(3): 192-209, 2003

Acute immobilization stress in prone position in susceptible Pietrain and resistant Duroc pigs. I: Comparison of protein degradation in Duroc and Pietrain pigs' skeletal muscle and liver. Journal of Animal Breeding & Genetics 117(4): 261-273, 2000

Acute immobilization stress in prone position in susceptible Pietrain and resistant Duroc pigs. II. Glycolytic metabolism in Pietrain and Duroc skeletal muscle and liver. Journal of Animal Breeding and Genetics 117(3): 203-210, 2000

Hormone and metabolite changes with stress in stress-susceptible pietrain pigs. Endocrine Regulations 28(2): 73-78, 1994

Reduction of heart lesions after experimental restraint stress: a study in stress-susceptible pigs. Zentralblatt für Veterinarmedizin. Reihe A 41(10): 722-730, 1994

Distribution and morphology of skeletal muscle lesions after experimental restraint stress in normal and stress-susceptible pigs. Journal of Veterinary Medicine Series A 42(9): 575-587, 1995

Catecholamines and 5-hydroxytryptamine levels in the pig brain: the effect of acute restraint stress. Animal Science Papers and Reports Polish Academy of Sciences, Institute of Genetics and Animal Breeding Jastrzebiec 13(4): 283-289, 1995

Absence of skeletal muscle lesions after experimental restraint stress induced by pancuronium in normal and stress-susceptible pigs. Journal of Veterinary Medicine Series A 43(3): 129-138, 1996

Polyamine levels in brain and plasma after acute restraint or water-immersion restraint stress in mice. Neuroscience Letters 355(1-2): 57-60, 2004

Acute and repeated restraint stress have little effect on pyridostigmine toxicity or brain regional cholinesterase inhibition in rats. Toxicological Sciences 69(1): 157-164, 2002

The influence of restraint immobilization stress on the concentration of bioamines and cortisol in plasma of Pietrain and Duroc pigs. Journal of Veterinary Medicine Series A 47(4): 231-242, 2000

Serum enzyme and electrolyte levels of stress-resistant Chester White pigs and stress-susceptible Poland China pigs. J. Anim. Sci, 31: 1168-1171, 1970

Effect of transport stress on plasma concentration of hormones related to stress and metabolism in Erhualian and Pietrain pigs. Chinese Journal of Applied and Environmental Biology 13(5): 681-685, 2007

Effect of acute stress on plasma levels of catecholamines and cortisol in addition to metabolites in stress-susceptible growing swine. Berliner und Munchener Tierarztliche Wochenschrift 109(10): 381-384, 1996