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The effect of selenium and/or vitamin E treatments on radiation-induced intestinal injury in rats

The effect of selenium and/or vitamin E treatments on radiation-induced intestinal injury in rats

Life Sciences 66(20): 1905-1913

ISSN/ISBN: 0024-3205

PMID: 10821115

DOI: 10.1016/s0024-3205(00)00516-6

The effect of pretreatment with selenium and/or vitamin E prior to whole abdominal irradiation was investigated in rats. Irradiation caused increased lipid peroxide and decreased GSH levels in the intestine. Intestinal superoxide dismutase and glutathione peroxidase activities were increased, but glutathione transferase activity decreased following irradiation. Selenium and/or vitamin E pretreatments ameliorated these disturbances in prooxidant-antioxidant balance.

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Accession: 003584964

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