Home
  >  
Section 4
  >  
Chapter 3,597

The transmission dynamics of the aetiological agent of scrapie in a sheep flock

Hagenaars, T.J.; Donnelly, C.A.; Ferguson, N.M.; Anderson, R.M.

Mathematical Biosciences 168(2): 117-135

2000

ISSN/ISBN: 0025-5564
PMID: 11121561
DOI: 10.1016/s0025-5564(00)00048-1
Accession: 003596367
Download citation:  
Text
  |  
BibTeX
  |  
RIS
We formulate and investigate the properties of a model framework to mimic the transmission dynamics of the aetiological agent of scrapie in a sheep flock. We derive expressions for summary parameters that characterize transmission scenarios, notably the basic reproduction number R0 and the mean generation time Tg. The timescale of epidemic outbreaks is expressed in terms of R0 and cumulants of the generation time distribution. We discuss the relative contributions to the overall rate of transmission of horizontal and vertical routes during invasion and in endemicity.

Full Text Article emailed within 0-6 h: $19.90




Related References

Hagenaars, T.J.; Donnelly, C.A.; Ferguson, N.M.; Anderson, R.M. 2003: Dynamics of a scrapie outbreak in a flock of Romanov sheep--estimation of transmission parameters Epidemiology and Infection 131(2): 1015-1022
Foster, J.; McKenzie, C.; Parnham, D.; Drummond, D.; Chong, A.; Goldman, W.; Hunter, N. 2006: Lateral transmission of natural scrapie to scrapie-free New Zealand sheep placed in an endemically infected UK flock Veterinary Record 159(19): 633-634
Foster, J.; McKenzie, C.; Parnham, D.; Drummond, D.; Goldmann, W.; Stevenson, E.; Hunter, N. 2006: Derivation of a scrapie-free sheep flock from the progeny of a flock affected by scrapie Veterinary Record 159(2): 42-45
Woolhouse, M.E.; Matthews, L.; Coen, P.; Stringer, S.M.; Foster, J.D.; Hunter, N. 1999: Population dynamics of scrapie in a sheep flock Philosophical Transactions of the Royal Society of London. Series B Biological Sciences 354(1384): 751-756
Stringer, S.M.; Hunter, N.; Woolhouse, M.E. 1998: A mathematical model of the dynamics of scrapie in a sheep flock Mathematical Biosciences 153(2): 79-98
Touzeau, S.; Chase-Topping, M.E.; Matthews, L.; Lajous, D.; Eychenne, F.; Hunter, N.; Foster, J.D.; Simm, G.; Elsen, J-M.; Woolhouse, M.E.J. 2006: Modelling the spread of scrapie in a sheep flock: evidence for increased transmission during lambing seasons Archives of Virology 151(4): 735-751
Pegoraro, R.J.; Ranjith, N. 2005: Plasminogen activator inhibitor type 1 (PAI-1) and platelet glycoprotein IIIa (PGIIIa) polymorphisms in young Asian Indians with acute myocardial infarction Cardiovascular Journal of South Africa: Official Journal for Southern Africa Cardiac Society and South African Society of Cardiac Practitioners 16(5): 266-270
Sabatier, P.; Durand, B.; Dubois, M.A.; Ducrot, C.; Calavas, D.; Wielle, A. van de 2004: Multiscale modelling of scrapie epidemiology: I. Herd level: a discrete model of disease transmission in a sheep flock Ecological Modelling 180(2/3): 233-252
Foster, J.; Toovey, L.; McKenzie, C.; Chong, A.; Parnham, D.; Drummond, D.; Hunter, N. 2008: Atypical scrapie in a sheep in a closed UK flock with endemic classical natural scrapie Veterinary Record 162(22): 723-724
Chatelain, J.; Dautheville-Guibal, C. 1989: Ovine scrapie: follow-up of sheep belonging to an endemic scrapie-infected flock European Journal of Epidemiology 5(1): 113-116
Simmons, H.A.; Simmons, M.M.; Spencer, Y.I.; Chaplin, M.J.; Povey, G.; Davis, A.; Ortiz-Pelaez, A.; Hunter, N.; Matthews, D.; Wrathall, A.E. 2009: Atypical scrapie in sheep from a UK research flock which is free from classical scrapie Bmc Veterinary Research 5: 8
Thorgeirsdottir, S.; Georgsson, G.; Reynisson, E.; Sigurdarson, S.; Palsdottir, A. 2002: Search for healthy carriers of scrapie: an assessment of subclinical infection of sheep in an Icelandic scrapie flock by three diagnostic methods and correlation with PrP genotypes Archives of Virology 147(4): 709-722
Goldmann, W.; Hunter, N.; Smith, G.; Foster, J.; Hope, J. 1994: PrP genotype and agent effects in scrapie: change in allelic interaction with different isolates of agent in sheep, a natural host of scrapie Journal of General Virology 75: 989-995
Cassmann, E.D.; Mammadova, N.; Moore, S.J.; Benestad, S.; Greenlee, J.J. 2021: Transmission of the atypical/Nor98 scrapie agent to Suffolk sheep with VRQ/ARQ, ARQ/ARQ, and ARQ/ARR genotypes Plos one 16(2): E0246503
Hamir, A.N.; Kunkle, R.A.; Bulgin, M.S.; Rohwer, R.G.; Gregori, L.; Richt, J.A. 2008: Experimental transmission of scrapie agent to susceptible sheep by intralingual or intracerebral inoculation Canadian Journal of Veterinary Research 72(1): 63-67
Truscott, J.E.; Ferguson, N.M. 2008: Transmission dynamics and mechanisms of endemicity of scrapie in the UK sheep population Epidemiology and Infection 137(6): 762-774
Ferguson, J.E.T.andN.M. 2009: Transmission Dynamics and Mechanisms of Endemicity of Scrapie in the Uk Sheep Population Epidemiology and Infection 137(6): 762-774
Hamir, A.N.; Kunkle, R.A.; Richt, J.A.; Miller, J.M.; Greenlee, J.J. 2008: Experimental transmission of US scrapie agent by nasal, peritoneal, and conjunctival routes to genetically susceptible sheep Veterinary Pathology 45(1): 7-11
Mammadova, N.; Cassmann, E.; Greenlee, J.J. 2020: Efficient transmission of classical scrapie agent x124 by intralingual route to genetically susceptible sheep with a low dose inoculum Research in Veterinary Science 132: 217-220
Jeffrey, M.; Witz, J.P.; Martin, S.; Hawkins, S.A.C.; Bellworthy, S.J.; Dexter, G.E.; Thurston, L.; González, L. 2015: Dynamics of the natural transmission of bovine spongiform encephalopathy within an intensively managed sheep flock Veterinary Research 46: 126