Section 4
Chapter 3,622

A high performance liquid chromatography method for simultaneous determination of albendazole metabolites in human serum

Mirfazaelian, A.; Dadashzadeh, S.; Rouini, M.R.

Journal of Pharmaceutical and Biomedical Analysis 30(4): 1249-1254


ISSN/ISBN: 0731-7085
PMID: 12408915
DOI: 10.1016/s0731-7085(02)00482-x
Accession: 003621358

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A simple assay for albendazole (ABZ) main metabolites - albendazole sulphoxide (ABZ-SO), albendazole sulphone (ABZ-SO2) and albendazole amino sulphone (ABZ-SO2-NH2) - in serum using HPLC was developed. The method involved liquid-liquid extraction of the serum by ethyl acetate, clean up with n-hexane and re-extraction with ethyl acetate, followed by separation on RP-C8 column with a mixture of methanol:acetonitrile:acetic acid:water (40:1:10:49) as the eluting solvent.

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