+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Characterization of a prolactin-regulated gene in reproductive tissues using the prolactin receptor knockout mouse model

Characterization of a prolactin-regulated gene in reproductive tissues using the prolactin receptor knockout mouse model

Biology of Reproduction 66(4): 1210-1218

Prolactin (PRL) exerts pleiotropic physiological effects in various cells and tissues, although it is mainly considered as a regulator of reproduction and cell growth. Null mutation of the prolactin receptor (PRLR) gene leads to female sterility due to a failure of embryo implantation. Using this mouse model and the method of mRNA differential display, we identified PRL target genes that are regulated during the peri-implantation period.

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 003675004

Download citation: RISBibTeXText

PMID: 11906943

Related references

Characterization of a Prolactin-Regulated Gene in Reproductive Tissues Usingthe Prolactin Receptor Knockout Mouse Model. Biology of Reproduction 66(4): 1210-1218, 2002

Completely humanizing prolactin rescues infertility in prolactin knockout mice and leads to human prolactin expression in extrapituitary mouse tissues. Endocrinology 154(12): 4777-4789, 2013

Prolactin actions accessed in the prolactin receptor knockout mouse. Journal of Endocrinology 164(Suppl ): S16, 2000

Molecular characterization of prolactin receptor (cPRLR) gene in chickens: gene structure, tissue expression, promoter analysis, and its interaction with chicken prolactin (cPRL) and prolactin-like protein (cPRL-L). Molecular and Cellular Endocrinology 370(1-2): 149-162, 2013

Inhibitory control of prolactin and Pit-1 gene promoters by dopamine. Dual signaling pathways required for D2 receptor-regulated expression of the prolactin gene. Journal of Biological Chemistry 266(34): 22919-22925, 1991

Novel reagents for human prolactin research: large-scale preparation and characterization of prolactin receptor extracellular domain, non-pegylated and pegylated prolactin and prolactin receptor antagonist. Protein Engineering Design and Selection 31(1): 7, 2018

Characterization of antisera to a partially purified prolactin receptor: effect on prolactin binding in different target tissues. Molecular and Cellular Endocrinology 34(3): 191-200, 1984

Prolactin signaling through the short isoform of the mouse prolactin receptor regulates DNA binding of specific transcription factors, often with opposite effects in different reproductive issues. Reproductive Biology and Endocrinology 7: 87, 2009

Prolactin receptor gene expression in the rabbit: identification, characterization and tissue distribution of several prolactin receptor messenger RNAs encoding a unique precursor. Molecular and Cellular Endocrinology 77(1-3): 181-192, 1991

Prolactin causes the dissociation of prolactin from plasma membrane receptor in lactating mouse mammary cell: action of high prolactin concentration. Endocrine Journal 43(1): 93, 1996

Characterization of multiple first exons in murine prolactin receptor gene and the effect of prolactin on their expression in the choroid plexus. Journal of Molecular Endocrinology 48(2): 169-176, 2012

Visualization of gene expression of short and long forms of prolactin receptor in rat reproductive tissues. Biology of Reproduction 49(3): 528-536, 1993

Possible role of prolactin on bovine luteal function and the gene expression of prolactin and prolactin receptor in corpus luteum throughout the estrous cycle. Biology of Reproduction 68(Suppl. 1): 140, 2003

Prolactin receptor and its actions: signal transduction pathways as determined by prolactin receptor knockout mice. Biochemical Society Transactions 29(1): A19.1-A19, 2001

Prolactin receptor signal transduction pathways and actions determined in prolactin receptor knockout mice. Biochemical Society Transactions 29(Pt 2): 48-52, 2001