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Characterization of a prolactin-regulated gene in reproductive tissues using the prolactin receptor knockout mouse model

Characterization of a prolactin-regulated gene in reproductive tissues using the prolactin receptor knockout mouse model

Biology of Reproduction 66(4): 1210-1218

ISSN/ISBN: 0006-3363

PMID: 11906943

DOI: 10.1095/biolreprod66.4.1210

Prolactin (PRL) exerts pleiotropic physiological effects in various cells and tissues, although it is mainly considered as a regulator of reproduction and cell growth. Null mutation of the prolactin receptor (PRLR) gene leads to female sterility due to a failure of embryo implantation. Using this mouse model and the method of mRNA differential display, we identified PRL target genes that are regulated during the peri-implantation period.

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Accession: 003675004

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