+ Translate
+ Most Popular
Gaucher's disease;thirty-two years experience at Siriraj Hospital
A study of Macrobathra Meyrick from China (Lepidoptera, Cosmopterigidae)
First occurrence in ores of tetragonal chalcocite
Effects of trace element nutrition on sleep patterns in adult women
N.Z. range management guidelines. 2. Design of grazing management systems for tussock country
A case of lipoma of the esophagus
A revision of world Acanthosomatidae (Heteroptera: Pentatomidae): keys to and descriptions of subfamilies, tribes and genera, with designation of types
Life history of the coronate scyphozoan Linuche unguiculata (Swartz, 1788)
Perceptual restoration of obliterated sounds
Mutagenicity studies on two chromium(III) coordination compounds
The formation of the skeleton. I. Growth of a long bone. 1st appearance of a center of calcification
Leucopenia and abnormal liver function in travellers on malaria chemoprophylaxis
The joint commission: four key root causes loom large in sentinel event data
Treatment of vitiligo with topical 15% lactic acid solution in combination with ultra violet-A
Behaviour of dairy cows within three hours after feed supply: I. Influence of housing type and time elapsing after feed supply
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Management and control of patients with type 2 diabetes mellitus in Lebanon: results from the International Diabetes Management Practices Study (IDMPS)
The diet composition and nutritional knowledge of patients with anorexia nervosa
Physoporella croatica Herak, 1958 of the Slovak karst Anisian (Slovakia, the West Carpathians Mts.)
Bright lights, big noise. How effective are vehicle warning systems?
Ein Plesiosaurier-Rest mit Magensteinen aus mittlerem Lias von Quedlinburg
Incidence of Chlamydia trachomatis in patients with sterility
Monster soup: the microscope and Victorian fantasy
Preliminary tests with residual sprays against poultry lice
Duration of the life of plants in phylogeny

Combined selenium and vitamin E deficiency causes fatal myopathy in guinea pigs

Combined selenium and vitamin E deficiency causes fatal myopathy in guinea pigs

Journal of Nutrition 131(6): 1798-1802

ISSN/ISBN: 0022-3166

PMID: 11385070

DOI: 10.1093/jn/131.6.1798

Selenium and vitamin E deficiencies were studied as part of an evaluation of oxidant defenses in guinea pigs. Male guinea pigs (100-120 g) were fed a control diet (C) or the diet without selenium (0 Se), without vitamin E (0 E), or without either selenium or vitamin E (0 Se-0 E). Between d 30 and 35, 7 of 13 guinea pigs fed the 0 Se-0 E diet were euthanized because of severe weakness of their extremities. No guinea pigs in the other diet groups developed weakness. Guinea pigs from each group were killed on d 37. Selenium deficiency and vitamin E deficiency were verified by measurement of glutathione peroxidase and alpha-tocopherol. Creatine phophokinase (CPK) activity was greater than controls in both groups fed vitamin E-deficient diets, but the increase was greater in the 0 Se-0 E group than in the 0 E group. Muscle F(2)-isoprostanes were greater than controls in both groups fed vitamin E-deficient diets with the level in the 0 Se-0 E group greater than that in the 0 E group. Histologic muscle necrosis was severe in the 0 Se-0 E group, minimal in the 0 E group and absent from other groups. The diets used in this study induced selenium and vitamin E deficiencies in guinea pigs. The study demonstrates that combined selenium and vitamin E deficiency results in a fatal myopathy in guinea pigs that is associated with lipid peroxidation in the affected muscle. This nutritional myopathy is much more severe than the myopathy that occurs with vitamin E deficiency alone.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 003683631

Download citation: RISBibTeXText

Related references

Fatal myopathy in guinea pigs caused by combined selenium and vitamin E deficiency. FASEB Journal 14(4): A295, 2000

Mitochondrial injury preceding myopathy in guinea pigs with combined selenium and vitamin E deficiency. FASEB Journal 16(5): A993-A994, 2002

Selenium and vitamin E deficiency in pigs. II. Influence on plasma selenium, vitamin E, ASAT and ALAT and on tissue selenium. Acta Veterinaria Scandinavica 20(2): 289-305, 1979

Bones, muscles and Vitamin C. I. The effect of a partial deficiency of vitamin C on the repair of bone and muscle in guinea-pigs. II. Partial deficiencies of Vitamin C and mid-diaphyseal thickenings of the tibia and fibula in guinea-pigs. III. Repair of the effects of total deprivation of vitamin C at the proximal ends of the tibia and fibula in guinea-pigs. Jour Anat 83(2/3-4): 158-174, 205-223, 285-295, 1949

Combined selenium and vitamin C deficiency causes cell death in guinea pig skeletal muscle. Nutrition Research 29(3): 213-219, 2009

Control of selenium-vitamin E deficiency in growing swine by parenteral administration of selenium-vitamin E preparations to baby pigs or to pregnant sows and their baby pigs. Journal of the American Veterinary Medical Association 163(5): 452-456, 1973

Vitamin E, selenium and polyunsaturated fatty acids in clinically normal grower (9-16 weeks old) pigs and their feed: their relationship to the vitamin E/selenium deficiency ("VESD") syndrome. New Zealand Veterinary Journal 36(3): 133-137, 1988

Effects of intramuscular injections of selenium and vitamin E on selenium-vitamin E deficiency in young pigs. American Journal of Veterinary Research 38(10): 1479-1484, 1977

Studies on vitamin E and selenium deficiency in young pigs. II. The hydrogen peroxide hemolysis test and the measure of red cell lipid peroxides as indices of vitamin E and selenium status. Canadian Journal of Comparative Medicine: Revue Canadienne de Medecine Comparee 41(1): 52-56, 1977

Amounts of eight combined elements required to induce selenium-vitamin E deficiency in ducklings and protection by supplements of selenium and vitamin E. American Journal of Veterinary Research 43(6): 1049-1055, 1982

Selenium in in vitamin-E-deficient diets and the occurrence of myopathy as a symptom of vitamin E deficiency. Nutrition and Metabolism 20(2): 91-94, 1976

Short Term Effects of Feeding Male Subjects with Glucose Syrup Fractions and D -Glucose. Annals of Nutrition and Metabolism 20(4): 209-221, 1976

Efficacy of selenium and vitamin E in prevention of selenium-vitamin E deficiency in pigs. Australian advances in veterinary science: 4, 1979

Nutritional myopathy in pigs fed a selenium-vitamin E deficient diet. Proceedings of the 54th annual conference, Perth, 9-13 May 1977: 141-142, 1977

Feed supplementation with selenium in relation to the vitamin E-selenium deficiency syndrome in pigs. Nordisk Veterinaermedicin 29(4-5): 161-165, 1977