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Comparative pharmacokinetics of metronidazole in camels, sheep and goats


Comparative pharmacokinetics of metronidazole in camels, sheep and goats



Acta Veterinaria Brno 72(1): 49-53



ISSN/ISBN: 0001-7213

The pharmacokinetics of metronidazole were determined after a single intramuscular (i.m.) dose of 30 mg.kg-1-body weight in five camels, sheep and goats. Marked differences were found between the three species in some of the kinetic parameters. For example, the elimination half-lives (t1/2; h) in camels, sheep and goats were 10.0, 6.21 and 5.87, respectively. The drug maximum concentrations in plasma, Cmax (mg.ml-1), were 28.3, 54.6 and 54.4 in camels, sheep and goats, respectively.

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Accession: 003685613

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