+ Translate
+ Most Popular
Sympathetic and visceral nerve blocks
What should be done after bee or wasp stings?
Anti-drool cheiloplasty: clinical results in six dogs
The biology of human starvation: some new insights
Vitamin B12 deficiency as a worldwide problem
Effect of daily gelatin ingestion on human scalp hair
On the nature and role of vivotoxins in plant disease
History of the discovery of vitamins by N. I. Lunin
Preliminary tests with residual sprays against poultry lice
MDU.1, a new mutant chilli variety
A study on compatibility of some insecticides with a fungicide on small cardamom (Elettaria cardamomum Maton.)
The cranial nerves of Mystus seenghala (Sykes)
The effects of prefrontal lobotomy on aggressive behavior in dogs
Human monkeypox: disease pattern, incidence and attack rates in a rural area of northern Zaire
The identity of the lipstick mold of cultivated mushrooms agaricus bisporus
Therapy for acne with saccharomyces boulardii
Advantages and disadvantages of bordeaux mixture and of lime-sulphur used on apples in the growing season
The composition of pampas-grass (Cortaderia argentea.)
Productivity of Pekin x Khaki Campbell ducks
A rapid survey of katydids (Insecta: Orthoptera: Tettigoniidae) of the Foret Classee du Pic de Fon, Guinea
Cranial nerves of Labeo rohita (Ham.)
Evaluating fundamentals of care: The development of a unit-level quality measurement and improvement programme
Life-cycle of the free-living nematode Pontonema vulgare in the White Sea
Grey leaf blight - a new disease of cocoa
Effect of foliar spray of urea and zinc sulphate on yield and fruit quality of Kinnow - 'a mandarin hybrid'

Comparing cancer risks between radiation and dioxin exposure based on two-stage model

Comparing cancer risks between radiation and dioxin exposure based on two-stage model

Environmetrics 14(2): 203-211

ISSN/ISBN: 1180-4009

DOI: 10.1002/env.577

This study investigates the use of the Moolgavkar two-stage model to compare the biological and statistical nature of cancer risks from dioxin exposure and from radiation exposure. The two-stage model is a biologically based stochastic model for carrying out statistical inferences of cancer risks using biologically motivated hypothesis. This article briefly describes the conditional likelihood for the model recently developed by the authors and then presents results obtained from applying it to dioxin dietary data in rats (Kociba et al., 1978) and radiation exposure data in mice. Comparing the results following the two different types of exposures based on the two-stage model confirms that the radiation exposure increases the initiation rates while the dioxin exposure increases the net-proliferation rate. The results indicate that the effect of TCDD at 100 ng/kg/day is an approximately 40 per cent increase in the net-proliferation rate in the intermediate cells. Portier et al. (1996b) and Moolgavkar et al. (1996) used the two-stage in-vivo initiation-promotion model in the rat liver. Measuring liver foci after administration of DEN followed by TCDD as a promoter, they observed an increase in proliferation rate in their initiated cells by 25-35 per cent. This closely agrees with our estimated increase of 40 per cent in the whole animal cancer incidence study of (Kociba et al., 1978). Another statistically important aspect obtained from the study is that the proportional hazards model is appropriate to apply to cancer incidence data following radiation exposure but is not appropriate for cancer risks following dioxin exposure.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 003686325

Download citation: RISBibTeXText

Related references

Comparing cancer risks between radiation and dioxin exposure based on two-stage model. Statistical Challenges in Environmental Health. Satellite Meeting (Fukuoka 2001-08) 14(2): 203-211, 2003

Cancer risks from low dose exposure to ionising radiation – Is the linear no-threshold model still relevant?. Radiography 18(1): 28-33, 2012

Cancer risks and radiation exposure from computed tomographic scans: how can we be sure that the benefits outweigh the risks?. Archives of Internal Medicine 169(22): 2049-2050, 2009

Risks associated with potential dioxin exposure through consumption of coffee brewed using bleached pulp-based filters. International Symposium 8 19(1-6): 873-876, 1989

Risks associated with potential dioxin exposure through consumption of coffee brewed using bleached pulp-based filters. Chemosphere 19(1-6): 873-876, 1989

The risks of undiagnosed cancer vs the theoretical risks of radiation exposure. Oncology 28(3): 165, 2014

Estimation of radiation-induced secondary cancer risks for early-stage non-small cell lung cancer patients after stereotactic body radiation therapy. Practical Radiation Oncology 7(3): E185-E194, 2017

Estimated risks of radon-induced lung cancer for different exposure profiles based on the new EPA model. Health Physics 88(4): 323-333, 2005

The two-stage clonal expansion model as an example of a biologically based model of radiation-induced cancer. Radiation Research 156(5 Pt 2): 678-681, 2001

Part 2 || The Two-Stage Clonal Expansion Model as an Example of a Biologically Based Model of Radiation-Induced Cancer. Radiation Research 156(5): 678-681, 2001

Lung cancer risks: comparing radiation with tobacco. Radiation Research 146(3): 356-357, 1996

Recurrent CT, cumulative radiation exposure, and associated radiation-induced cancer risks from CT of adults. Radiology 251(1): 175-184, 2009

Recurrent CT, Cumulative Radiation Exposure, and Associated Radiation-induced Cancer Risks from CT of Adults. Yearbook of Diagnostic Radiology 2010: 193-195, 2010

Comparison of radiation exposure and associated radiation-induced cancer risks from mammography and molecular imaging of the breast. Medical Physics 37(12): 6187-6198, 2010

Projected lifetime cancer risks from occupational radiation exposure among diagnostic medical radiation workers in South Korea. Bmc Cancer 18(1): 1206, 2018