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Comparison of in vitro activities of gatifloxacin and ciprofloxacin against four taxa of rapidly growing mycobacteria

Comparison of in vitro activities of gatifloxacin and ciprofloxacin against four taxa of rapidly growing mycobacteria

Antimicrobial Agents and ChemoTherapy 46(10): 3283-3285

ISSN/ISBN: 0066-4804

PMID: 12234861

DOI: 10.1128/aac.46.10.3283-3285.2002

By using current NCCLS broth microdilution methods, we found that gatifloxacin inhibited 90% of Mycobacterium fortuitum group isolates (n=39) at <=0.12 micro g/ml, 90% of M. mucogenicum isolates (n=20) at <=0.25 micro g/ml, and 90% of M. chelonae isolates (n=32) at <=4 micro g/ml. Gatifloxacin can only inhibit 90% M. abscessus isolates (n=24) at >32 micro g/ml. Gatifloxacin was generally fourfold more active than ciprofloxacin.

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Accession: 003687556

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