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Comparison of the complete DNA sequences of the Oka varicella vaccine and its parental virus


Comparison of the complete DNA sequences of the Oka varicella vaccine and its parental virus



Journal of Virology 76(22): 11447-11459



ISSN/ISBN: 0022-538X

PMID: 12388706

DOI: 10.1128/jvi.76.22.11447-11459.2002

The DNA sequences of the Oka varicella vaccine virus (V-Oka) and its parental virus (P-Oka) were completed. Comparison of the sequences revealed 42 base substitutions, which led to 20 amino acid conversions and length differences in tandem repeat regions (R1, R3, and R4) and in an origin of DNA replication. Amino acid substitutions existed in open reading frames (ORFs) 6, 9A, 10, 21, 31, 39, 50, 52, 55, 59, 62, and 64.

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Accession: 003688426

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