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Comparison of the post-transcriptional regulation of the mRNAs for the surface proteins PSA (GP46) and MSP (GP63) of Leishmania chagasi


Comparison of the post-transcriptional regulation of the mRNAs for the surface proteins PSA (GP46) and MSP (GP63) of Leishmania chagasi



Journal of Biological Chemistry 277(19): 16489-16497



ISSN/ISBN: 0021-9258

PMID: 11856749

DOI: 10.1074/jbc.m200174200

MSP (major surface proteinase; GP63) and PSA (parasite-specific antigen; GP46) are abundant 63- and 46-kDa glycolipid-anchored proteins on the surface of the promastigote form of most Leishmania species. MSP is a zinc metalloprotease that confers resistance to host complement-mediated lysis. PSA contains internal repeats of 24 amino acids, and its function is unknown.

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Accession: 003688625

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