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Concentrations of granulocyte colony-stimulating factor in human milk after in vitro simulations of digestion


Concentrations of granulocyte colony-stimulating factor in human milk after in vitro simulations of digestion



Pediatric Research 46(6): 767-771



ISSN/ISBN: 0031-3998

PMID: 10590037

Human milk contains proteins that survive digestion in the neonatal gastrointestinal tract. Our group and others have reported that granulocyte colony-stimulating factor (G-CSF), a haematopoietic cytokine that influences neutrophil proliferation and differentiation, is present in human milk. We also reported that specific receptors for G-CSF are expressed on the villous enterocytes of neonates. However, the physiological role of milk-borne G-CSF is not known.

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