Home
  >  
Section 4
  >  
Chapter 3,691

Conditions that may affect the results of susceptibility testing of Mycobacterium tuberculosis to pyrazinamide

Zhang, Y.; Permar, S.; Sun, Z.

Journal of Medical Microbiology 51(1): 42-49

2002

ISSN/ISBN: 0022-2615
PMID: 11800471
DOI: 10.1099/0022-1317-51-1-42
Accession: 003690906
Download citation:  
Text
  |  
BibTeX
  |  
RIS
Pyrazinamide (PZA) is an important front-line anti-tuberculosis drug that is active only at acid pH. However, acid pH causes significant difficulty for PZA susceptibility testing. A common problem in PZA testing is false resistance caused by large bacterial inocula. This study investigated the relationship of false resistance to numbers of bacilli, pH and other factors that potentially affect susceptibility to PZA.

PDF emailed within 0-6 h: $19.90




Related References

Chedore, P.; Bertucci, L.; Wolfe, J.; Sharma, M.; Jamieson, F. 2010: Potential for erroneous results indicating resistance when using the Bactec MGIT 960 system for testing susceptibility of Mycobacterium tuberculosis to pyrazinamide Journal of Clinical Microbiology 48(1): 300-301
Aono, A.; Hirano, K.; Hamasaki, S.; Abe, C. 2002: Evaluation of BACTEC MGIT 960 PZA medium for susceptibility testing of Mycobacterium tuberculosis to pyrazinamide (PZA): compared with the results of pyrazinamidase assay and Kyokuto PZA test Diagnostic Microbiology and Infectious Disease 44(4): 347-352
Piersimoni, C.; Mustazzolu, A.; Giannoni, F.; Bornigia, S.; Gherardi, G.; Fattorini, L. 2013: Prevention of false resistance results obtained in testing the susceptibility of Mycobacterium tuberculosis to pyrazinamide with the Bactec MGIT 960 system using a reduced inoculum Journal of Clinical Microbiology 51(1): 291-294
Morlock, G.P.; Tyrrell, F.C.; Baynham, D.; Escuyer, V.E.; Green, N.; Kim, Y.; Longley-Olson, P.A.; Parrish, N.; Pennington, C.; Tan, D.; Austin, B.; Posey, J.E. 2017: Using Reduced Inoculum Densities of Mycobacterium tuberculosis in MGIT Pyrazinamide Susceptibility Testing to Prevent False-Resistant Results and Improve Accuracy: A Multicenter Evaluation Tuberculosis Research and Treatment 2017: 3748163
Salfinger, M.; Kafader, F.M. 1987: Susceptibility testing of Mycobacterium tuberculosis to pyrazinamide Zentralblatt für Bakteriologie Mikrobiologie und Hygiene. Series A Medical Microbiology Infectious Diseases Virology Parasitology 265(3-4): 404-407
The Editors 2002: Susceptibility testing of Mycobacterium tuberculosis to pyrazinamide Journal of Medical Microbiology 51(1): 11-12
Huang, Z.-K.; Luo, Q.; Jiang, B.-X.; Li, W.-T.; Xu, X.-M.; Xiong, G.-L.; Li, J.-M. 2013: Performance of the microscopic observation drug susceptibility assay in pyrazinamide susceptibility testing for Mycobacterium tuberculosis Chinese Medical Journal 126(22): 4334-4339
Tarrand, J.J.; Spicer, A.; Groschel, D.H.M. 1983: Radiometric pyrazinamide susceptibility testing of mycobacterium tuberculosis Abstracts of the Annual Meeting of the American Society for Microbiology 83: C226
Zimic, M.; Loli, S.; Gilman, R.H.; Gutierrez, A.és.; Fuentes, P.; Cotrina, M.; Kirwan, D.; Sheen, P. 2012: A new approach for pyrazinamide susceptibility testing in Mycobacterium tuberculosis Microbial Drug Resistance 18(4): 372-375
Bai, G.H.; Kim, S.J. 1983: Study on the Pyrazinamide Susceptibility Testing of Mycobacterium Tuberculosis Tuberculosis and Respiratory Diseases 30(3): 103-112
Dormandy, J.; Somoskovi, A.; Kreiswirth, B.N.; Driscoll, J.R.; Ashkin, D.; Salfinger, M. 2007: Discrepant results between pyrazinamide susceptibility testing by the reference BACTEC 460TB method and pncA DNA sequencing in patients infected with multidrug-resistant W-Beijing Mycobacterium tuberculosis strains Chest 131(2): 497-501
Li, H.; Zhou, L.-P.; Luo, J.; Yu, J.-P.; Yang, H.; Wei, H.-P. 2016: Rapid colorimetric pyrazinamide susceptibility testing of Mycobacterium tuberculosis International Journal of Tuberculosis and Lung Disease: the Official Journal of the International Union Against Tuberculosis and Lung Disease 20(4): 462-467
Ashtekar, D.R.; Fernandes, F.; Kale, R.N.; Virde, B.S.; Khadse, B.G.; Devdhar, M.N.; Ganatra, R.D.; Shah, D.H.; Shirodkar, M.V.N.; Deshpande, V.R. 1985: Rapid indirect pyrazinamide susceptibility testing of mycobacterium tuberculosis IRCS (International Research Communications System) Medical Science 13(8): 736-737
Heifets, L.; Sanchez, T. 2000: New agar medium for testing susceptibility of Mycobacterium tuberculosis to pyrazinamide Journal of Clinical Microbiology 38(4): 1498-1501
Butler, W.R.; Kilburn, J.O. 1982: Improved method for testing susceptibility of Mycobacterium tuberculosis to pyrazinamide Journal of Clinical Microbiology 16(6): 1106-1109
Salfinger, M.; Reller, L.B.; Demchuk, B.; Johnson, Z.T. 1989: Rapid radiometric method for pyrazinamide susceptibility testing of Mycobacterium tuberculosis Research in Microbiology 140(4-5): 301-309
Tarrand, J.J.; Spicer, A.D.; Gröschel, D.H. 1986: Evaluation of a radiometric method for pyrazinamide susceptibility testing of Mycobacterium tuberculosis Antimicrobial Agents and ChemoTherapy 30(6): 852-855
Fredricks, B.A.; DeCoster, D.J.; Kim, Y.; Sparks, N.; Callister, S.M.; Schell, R.F. 2006: Rapid pyrazinamide susceptibility testing of Mycobacterium tuberculosis by flow cytometry Journal of Microbiological Methods 67(2): 266-272
Demers, A-Marie.; Venter, A.; Friedrich, S.O.; Rojas-Ponce, G.; Mapamba, D.; Jugheli, L.; Sasamalo, M.; Almeida, D.; Dorasamy, A.; Jentsch, U.; Gibson, M.; Everitt, D.; Eisenach, K.D.; Diacon, A.H. 2016: Direct Susceptibility Testing of Mycobacterium tuberculosis for Pyrazinamide by Use of the Bactec MGIT 960 System Journal of Clinical Microbiology 54(5): 1276-1281
Cunha, J. 2012: Pyrazinamide susceptibility testing in all isolates of the Mycobacterium tuberculosis complex - a critical analysis Revista Portuguesa de Pneumologia 18(4): 188-189