Section 4
Chapter 3,691

Conditions that may affect the results of susceptibility testing of Mycobacterium tuberculosis to pyrazinamide

Zhang, Y.; Permar, S.; Sun, Z.

Journal of Medical Microbiology 51(1): 42-49


ISSN/ISBN: 0022-2615
PMID: 11800471
DOI: 10.1099/0022-1317-51-1-42
Accession: 003690906

Download citation:  

Pyrazinamide (PZA) is an important front-line anti-tuberculosis drug that is active only at acid pH. However, acid pH causes significant difficulty for PZA susceptibility testing. A common problem in PZA testing is false resistance caused by large bacterial inocula. This study investigated the relationship of false resistance to numbers of bacilli, pH and other factors that potentially affect susceptibility to PZA.

PDF emailed within 0-6 h: $19.90