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Consumption of watercress fails to alter coumarin metabolism in humans

Consumption of watercress fails to alter coumarin metabolism in humans

Drug Metabolism and Disposition: the Biological Fate of Chemicals 29(6): 786-788

Watercress is an excellent source of phenethyl isothiocyanate (PEITC), an effective inhibitor of nitrosamine carcinogenesis in rodents. The mechanism of inhibition is believed to be due in part to inhibition of cytochrome P450 (P450) enzymes. P450 2A6 is a catalyst for the metabolic activation of several nitrosamines.

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Accession: 003692604

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PMID: 11353744

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