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Control of muscle protein synthesis as a result of contractile activity and amino acid availability: implications for protein requirements


Control of muscle protein synthesis as a result of contractile activity and amino acid availability: implications for protein requirements



International Journal of Sport Nutrition and Exercise Metabolism 11(Suppl): S170-S176



ISSN/ISBN: 1526-484X

DOI: 10.1123/ijsnem.11.s1.s170

The major anabolic influences on muscle are feeding and contractile activity. As a result of feeding, anabolism occurs chiefly by increases in protein synthesis with minor changes in protein breakdown. Insulin has a permissive role in increasing synthesis, but the availability of amino acids is crucial for net anabolism. We have investigated the role of amino acids in stimulating muscle protein synthesis, the synergy between exercise and amino acid availability, and some of the signaling elements involved. The results suggest that muscle is acutely sensitive to amino acids, that exercise probably increases the anabolic effects of amino acids by a separate pathway, and that for this reason it is unlikely that accustomed physical exercise increases protein requirements.

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Accession: 003694136

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Control of muscle protein synthesis as a result of contractile activity and amino acid availability: implications for protein requirements. International Journal of Sport Nutrition and Exercise Metabolism 11(Suppl): S170-S176, 2001

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