The effect of restraint and isolation stress (RIS) on plasma cortisol and catecholamines profile was studied in 12 adult Black Bengal female goats which were randomly allotted into experimental (n=6) and control (n=6) groups. Experimental goats were kept individually in metabolic trial cages and isolated for 6 h on each of the six consecutive days, whereas the control goats remained undisturbed in the flock.