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Coumarins isolated from Angelica gigas inhibit acetylcholinesterase: structure-activity relationships

Coumarins isolated from Angelica gigas inhibit acetylcholinesterase: structure-activity relationships

Journal of Natural Products 64(5): 683-685

ISSN/ISBN: 0163-3864

PMID: 11374978

DOI: 10.1021/np000441w

Acetylcholinesterase (AChE) inhibitory activity-guided fractionation of Angelica gigas led to isolation and identification of a new coumarin, peucedanone (12), and isolation of 11 known coumarins. Among them, decursinol (1) represented the highest inhibitory activity toward AChE in vitro. The correlation of the inhibitory activities of the coumarins toward AChE with their chemical structures was studied.

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Accession: 003696277

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