EurekaMag
+ Translate
+ Most Popular
Investigations on the organic drift in North Swedish streams
Limitations of Using Microsoft Excel Version 2016 (MS Excel 2016) for Statistical Analysis for Medical Research
Phloem necrosis of coffee in Surinam
Anatomy of Mystus seenghala IV Nervous system
Integrated farming system for gardenland conditions of Coimbatore district - an over view
Tetrapleure (Tetrapleura tetraptera), an unknown African medicinal and spice plant
The origin and phylogenetic significance of the trochophoran larvae 2. evolutionary significance of the larvae of coelomate worms and mollusks
Comparison of rice bran and maize bran as feeds for growing and fattening pigs
Enterobacter amnigenus. An unusual human pathogen
Influence of Seriboost foliar application on leaf yield and leaf protein content in mulberry (Morus spp.), in relation to silkworm cocoon production
The identity of the lipstick mold of cultivated mushrooms agaricus bisporus
Advantages and disadvantages of bordeaux mixture and of lime-sulphur used on apples in the growing season
'Pan-sukh' disease of Rice in the Central Provinces
Geological age of the Ptilophyllum flora; a critical reassessment
Study of vitellogenesis in birds; physiological phases & role of folliculin in vitellogenesis
Evaluation of WCT coconut and Komadan coconut
Therapy for acne with saccharomyces boulardii
Evidence for Late Cretaceous N-S dextral shear in the west-central crystalline core, North Cascades, Washington
'Rajeshwari' - a high-yielding white seeded variety of sesame for Andhra Pradesh
Manufacture of Ricotta cheese from whey fortified with skim milk powder using different acidulants
Occurrence of Eutrichophilus mexicanus (Rudow, 1866) and Eutrichophilus lobatus (Ewing, 1936) (Phthiraptera: Trichodectidae) on Sphiggurus villosus (Cuvier, 1825) (Rodentia: Erethizontidae) in Rio de
Factors affecting fruitfulness in durian (Durio zibethinus Murr.). I. Flowering and pollination
Bronchial cuff pressure change caused by left-sided double-lumen endobronchial tube displacement
Some Biological Applications of Organometallic Compounds
The composition of pampas-grass (Cortaderia argentea.)

Coumarins isolated from Angelica gigas inhibit acetylcholinesterase: structure-activity relationships


Coumarins isolated from Angelica gigas inhibit acetylcholinesterase: structure-activity relationships



Journal of Natural Products 64(5): 683-685



ISSN/ISBN: 0163-3864

PMID: 11374978

DOI: 10.1021/np000441w

Acetylcholinesterase (AChE) inhibitory activity-guided fractionation of Angelica gigas led to isolation and identification of a new coumarin, peucedanone (12), and isolation of 11 known coumarins. Among them, decursinol (1) represented the highest inhibitory activity toward AChE in vitro. The correlation of the inhibitory activities of the coumarins toward AChE with their chemical structures was studied.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 003696277

Download citation: RISBibTeXText

Related references

Neuroprotective coumarins from the root of Angelica gigas: structure-activity relationships. Archives of Pharmacal Research 30(11): 1368-1373, 2007

Simultaneous determination of eight coumarins in Angelica gigas and in various other Angelica species by high performance liquid chromatography and comparative micro-morphology study of Angelica species. Planta Medica 73(14): 1509-1516, 2007

Coumarins from Angelica decursiva inhibit α-glucosidase activity and protein tyrosine phosphatase 1B. Chemico-Biological Interactions 252: 93-101, 2016

Gigasol and other coumarins from Angelica gigas. Phytochemistry 1991(2): 710-712, 1991

Antibacterial coumarins from Angelica gigas roots. Archives of Pharmacal Research 26(6): 449-452, 2003

Coumarins from the root of Angelica gigas Nakai. Chemical and Pharmaceutical Bulletin 16(6): 1139-1140, 1968

Cytotoxic coumarins from roots of Angelica gigas Nakai. Natural Medicines 48(4): 334-335, 1994

New coumarins isolated from the roots of Angelica anomala Lall. and Angelica cartilaginomarginata (Makino) Nakai (Umbelliferae). Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan 87(9): 1118-1124, 1967

In Silico Studies and In Vivo MAO A Inhibitory Activity of Coumarins Isolated from Angelica archangelica Extract: An Approach toward Antidepressant Activity. Acs Omega 5(25): 15069-15076, 2020

Antidiabetic activity of angelan isolated from Angelica gigas Nakai. Archives of Pharmacal Research 31(11): 1489-1496, 2008

Platelet anti-aggregatory effects of coumarins from the roots of Angelica genuflexa and A. gigas. Archives of Pharmacal Research 26(9): 723-726, 2003

Structures of new coumarins and antitumor-promoting activity of coumarins from Angelica edulis. Planta Medica 60(4): 333-336, 1994

Antifungal Activity of Decursinol Angelate Isolated from Angelica gigas Roots Against Puccinia recondita. Research in Plant Disease 17(1): 25-31, 2011

Anti-Alzheimer's disease potential of coumarins from Angelica decursiva and Artemisia capillaris and structure-activity analysis. Asian Pacific Journal of Tropical Medicine 9(2): 103-111, 2016

Quantitative analysis of marker compounds in Angelica gigas, Angelica sinensis, and Angelica acutiloba by HPLC/DAD. Chemical and Pharmaceutical Bulletin 63(7): 504-511, 2015