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Cross-binding between Plasmodium falciparum CTL epitopes and HLA class I molecules

Cross-binding between Plasmodium falciparum CTL epitopes and HLA class I molecules

Immunological Investigations 32(1-2): 31-41

ISSN/ISBN: 0882-0139

PMID: 12722940

DOI: 10.1081/imm-120019206

Plasmodium falciparum CTL epitope minigenes containing HLA-A2 and HLA-B7 subtype supermotifs were cloned into a plasmid expression vector; this expression was measured in eight human HLA class I molecule specific cell lines. Three assays for in vitro antigen presentation analysis were developed to examine the cross-binding between CTL epitopes and HLA class I molecules, including cell surface peptide-MHC class I binding assay, binding stabilization assay and MHC class I assembling assay. The results demonstrated that the HLA-B51 restricted CTL epitope of Plasmodium falciparum could be presented by other HLA class I molecules; however, no other presentation was found for HLA-A2.1 CTL epitope. This work suggests the possibility for improved vaccine-coverage rates by development of a CTL vaccine which contains epitopes capable of cross-binding among different MHC class I alleles.

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Accession: 003697281

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