EurekaMag
+ Translate
+ Most Popular
Advantages and disadvantages of bordeaux mixture and of lime-sulphur used on apples in the growing season
Observations on the Umaria marine bed
10 years of hearing conservation in the Royal Air Force
Chocolate crumb - dairy ingredient for milk chocolate
Effect of daily gelatin ingestion on human scalp hair
Comparison of rice bran and maize bran as feeds for growing and fattening pigs
The composition of pampas-grass (Cortaderia argentea.)
The Accraian Series:
The mechanism of the Liebermann-Burchard reaction of sterols and triterpenes and their esters
Cerebrovascular Doppler ultrasound studies (cv-Doppler)
Toria: PT-303 - first national variety
Hair growth promoting activity of tridax procumbens
Productivity of Pekin x Khaki Campbell ducks
A stable cytosolic expression of VH antibody fragment directed against PVY NIa protein in transgenic potato plant confers partial protection against the virus
Solar treatment of wheat loose smut
Swimmers itch in the Lake of Garda
Bactofugation and the Bactotherm process
The effects of prefrontal lobotomy on aggressive behavior in dogs
Visual rating scales for screening whorl-stage corn for resistance to fall armyworm
Breakdown of seamounts at the trench axis, viewed from gravity anomaly
Kooken; pennsylvania's toughest cave
Recovery of new dinosaur and other fossils from the Early Cretaceous Arundel Clay facies (Potomac Group) of central Maryland, U.S.A
Zubor horny (Bison bonasus) v prirodnych podmienkach Slovensku
The extended Widal test in the diagnosis of fevers due to Salmonella infection
Hair of the american mastodon indicates an adaptation to a semi aquatic habitat

Cubitus interruptus acts to specify naked cuticle in the trunk of Drosophila embryos


Cubitus interruptus acts to specify naked cuticle in the trunk of Drosophila embryos



Developmental Biology 241(1): 132-144



ISSN/ISBN: 0012-1606

PMID: 11784100

DOI: 10.1006/dbio.2001.0498

One function of the Wingless signaling pathway is to determine the naked, cuticle cell fate choice in the trunk epidermis of Drosophila larvae. The zinc finger protein Teashirt binds to the transactivator domain of Armadillo to modulate Wingless signaling output in the embryonic trunk and contributes to the naked cell fate choice. The Hedgehog pathway is also necessary for the correct specification of larval epidermal cell fate, which signals via the zinc finger protein, Cubitus interruptus. Here, we show that Cubitus interruptus also has a Wingless-independent function, which is required for the specification of the naked cell fate; previously, it had been assumed that Ci induces naked cuticle exclusively by regulation of wg. Wg and Hh signaling pathways may be acting combinatorially in the same, or individually in different, cells for this process, by regulating common sets of target genes. First, the loss of the naked cuticular phenotype in embryos lacking cubitus interruptus activity is very similar to that induced by a late loss of Wingless function. Second, overexpression of Cubitus interruptus causes the suppression of denticles (as Wingless does) in absence of Wingless activity in the anterior trunk. Using epistasis experiments, we conclude that different combinations of the three proteins Teashirt, Cubitus interruptus, and Armadillo are employed for the specification of naked cuticle at distinct positions both along the antero-posterior axis and within individual trunk segments. Finally, biochemical approaches suggest the existence of protein complexes consisting of Teashirt, Cubitus interruptus, and Armadillo.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 003697936

Download citation: RISBibTeXText

Related references

The response in drosophila melanogaster of the cubitus interruptus wallace gene to a genetic background selected for low expression of the cubitus interruptus allele. Genetics 83(3 Part 1): S33-S34, 1976

Genetic evidence for a protein kinase A/cubitus interruptus complex that facilitates processing of cubitus interruptus in Drosophila. Genetics 158(3): 1157-1166, 2001

Drosophila CBP homologue acts as a co-activator for Cubitus interruptus in the hedgehog signaling pathway. Society for Neuroscience Abstracts 23(1-2): 1407, 1997

Analysis of cubitus interruptus regulation in Drosophila embryos and imaginal disks. Development 121(6): 1625-1635, 1995

The expression of alleles at the cubitus interrupts locus in hybrids between Drosophila melanogaster and Drosophila simulans. Genetics 34(3): 315-327, 1949

Cubitus interruptus requires Drosophila CREB-binding protein to activate wingless expression in the Drosophila embryo. Molecular and Cellular Biology 20(5): 1616-1625, 2000

Drosophila CBP is a co-activator of cubitus interruptus in hedgehog signalling. Nature 386(6626): 735-738, 1997

Genetic dissection of the Drosophila Cubitus interruptus signaling complex. Developmental Biology 236(2): 411-420, 2001

Cubitus Interruptus, a New Genovariation of the Fourth Chromosome of DROSOPHILA MELANOGASTER. Genetics 18(2): 117-120, 1933

Cubitus interruptus-independent transduction of the Hedgehog signal in Drosophila. Development 127(24): 5509-5522, 2000

Proteolysis of cubitus interruptus in Drosophila requires phosphorylation by protein kinase A. Development 126(19): 4331-4339, 1999

The position effects Bar, white-mottled, and cubitus interruptus in Drosophila melanogaster. Genetics 35(1): 112-113, 1950

Studies on the Position Effect at the Cubitus Interruptus Locus of Drosophila Melanogaster. Genetics 40(3): 343-373, 1955

Regulation of the Drosophila transcription factor, Cubitus interruptus, by two conserved domains. Developmental Biology 291(2): 368-381, 2006

Interactions of the abruptex and cubitus interruptus dominant mutants in drosophila melanogaster. Genetics 80(3 Part 1): S42-S43, 1975