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Cyclin-dependent kinase 8 is expressed both maternally and zygotically during zebrafish embryo development

Cyclin-dependent kinase 8 is expressed both maternally and zygotically during zebrafish embryo development

Biochimica et Biophysica Acta 1576(1-2): 203-208

ISSN/ISBN: 0006-3002

PMID: 12031503

DOI: 10.1016/s0167-4781(02)00302-0

Cyclin-dependent kinase 8 (cdk8) regulates transcription by phosphorylating RNA polymerase II and TFIIH. The mechanism of zygotic transcription activation during vertebrate embryonic development is poorly understood. Here we describe the cloning and developmental expression pattern of zebrafish (Danio rerio) cdk8 mRNA. It is highly conserved, sharing 79% DNA and 95% amino acid sequence identity with human cdk8, thereby indicating an important role for the protein.

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Accession: 003699270

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