EurekaMag
+ Translate
+ Most Popular
Advantages and disadvantages of bordeaux mixture and of lime-sulphur used on apples in the growing season
Observations on the Umaria marine bed
10 years of hearing conservation in the Royal Air Force
Chocolate crumb - dairy ingredient for milk chocolate
Effect of daily gelatin ingestion on human scalp hair
Comparison of rice bran and maize bran as feeds for growing and fattening pigs
The composition of pampas-grass (Cortaderia argentea.)
The Accraian Series:
The mechanism of the Liebermann-Burchard reaction of sterols and triterpenes and their esters
Cerebrovascular Doppler ultrasound studies (cv-Doppler)
Toria: PT-303 - first national variety
Hair growth promoting activity of tridax procumbens
Productivity of Pekin x Khaki Campbell ducks
A stable cytosolic expression of VH antibody fragment directed against PVY NIa protein in transgenic potato plant confers partial protection against the virus
Solar treatment of wheat loose smut
Swimmers itch in the Lake of Garda
Bactofugation and the Bactotherm process
The effects of prefrontal lobotomy on aggressive behavior in dogs
Visual rating scales for screening whorl-stage corn for resistance to fall armyworm
Breakdown of seamounts at the trench axis, viewed from gravity anomaly
Kooken; pennsylvania's toughest cave
Recovery of new dinosaur and other fossils from the Early Cretaceous Arundel Clay facies (Potomac Group) of central Maryland, U.S.A
Zubor horny (Bison bonasus) v prirodnych podmienkach Slovensku
The extended Widal test in the diagnosis of fevers due to Salmonella infection
Hair of the american mastodon indicates an adaptation to a semi aquatic habitat

Cytotoxicity for porcine islet cells by complement of six animal species


Cytotoxicity for porcine islet cells by complement of six animal species



Journal of Veterinary Medical Science 65(10): 1107-1109



ISSN/ISBN: 0916-7250

PMID: 14600349

DOI: 10.1292/jvms.65.1107

Complement-mediated cytotoxicity for porcine islet cells (PICs) was evaluated using sera of six animal species. Then soluble complement receptor type-1 (sCR1) as an anti-complement agent was added to those sera, and the changes in 50% hemolytic unit of complement serum (CH50) and cytotoxic effect of those sera on PICs were examined. All the sera except for that of pig showed cytotoxicity. However, the extent of toxicity was considerably different between species. In the rat and human serum, sCR1 significantly reduced CH50 and cytotoxicity, however in the dog serum, sCR1 had no suppressive effects. These results may suggest that complement contribute to humoral cytotoxicity for PICs as a main factor, and the compatibility of complement with PICs differs between animal species.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 003700069

Download citation: RISBibTeXText

Related references

Absence of cytotoxicity of islet cell surface antibodies in vivo despite complement-mediated cytotoxic effects to islet cells in vitro. Biomedica Biochimica Acta 43(5): 663-673, 1984

A comparison of fetal and adult porcine islets with regard to Gal alpha (1,3)Gal expression and the role of human immunoglobulins and complement in islet cell cytotoxicity. Transplantation 69(8): 1711-1717, 2000

Effect of syngeneic islet antigen administration on complement-dependent antibody-mediated cytotoxicity to islet cells and diabetes onset in diabetes-prone BB/OK rats. Autoimmunity 14(4): 283-289, 1993

Protection of porcine endothelial cells from complement-mediated cytotoxicity by the human complement regulators CD59, C1 inhibitor, and soluble complement receptor type 1. Analysis in a pig-to-human in vitro model relevant to hyperacute xenograft rejection. Transplantation 62(11): 1693-1696, 1996

Complement-dependent cytotoxicity of monoclonal antibodies against islet cells. Biomedica Biochimica Acta 44(1): 117-121, 1985

An approach of the cytotoxicity of human complement to porcine endothelial cells. Zhonghua Weishengwuxue He Mianyixue Zazhi 17(2): 114-117, 1997

Gal alpha(1,3)Gal expression on neonatal porcine islet cells and susceptibility to human antibody/complement lysis. Transplantation Proceedings 30(2): 325, 1998

Expression of GAL-alpha Gal on neonatal porcine islet cells and their susceptibility to human antibody-complement lysis. Acta Diabetologica 34(2): 111, 1997

Complement-fixing islet cell antibodies in type-1 diabetes can trigger the assembly of the terminal complement complex on human islet cells and are potentially cytotoxic. Clinical Immunology and Immunopathology 79(3): 217-223, 1996

Removal of terminal alpha-galactosyl residues from xenogeneic porcine endothelial cells. Decrease in complement-mediated cytotoxicity but persistence of IgG1-mediated antibody-dependent cell-mediated cytotoxicity. Transplantation 62(1): 105-113, 1996

Early appearance of complement-dependent antibody mediated cytotoxicity (C'AMC) to islet cells in serum of diabetes-prone BB/OK rats. Diabetes Research 13(4): 183-186, 1990

Complement dependent antibody mediated cytotoxicity camc to islet cells in diabetes prone bb ok rats and their congenic derivatives. European Journal of Clinical Investigation 20(2 Part 2): A20, 1990

Complement dependent cytotoxicity in chronic lymphocytic leukemia: ofatumumab enhances alemtuzumab complement dependent cytotoxicity and reveals cells resistant to activated complement. Leukemia and Lymphoma 53(11): 2218-2227, 2012

Porcine islet cells of Langerhans are destroyed by human complement and not by antibody-dependent cell-mediated mechanisms. Transplantation 62(1): 29-33, 1996

Expression of Gal alpha(1,3)gal on neonatal porcine islet beta-cells and susceptibility to human antibody/complement lysis. Diabetes 47(9): 1406-1411, 1998