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Defective fatty acid uptake modulates insulin responsiveness and metabolic responses to diet in CD36-null mice

Defective fatty acid uptake modulates insulin responsiveness and metabolic responses to diet in CD36-null mice

Journal of Clinical Investigation 109(10): 1381-1389

ISSN/ISBN: 0021-9738

PMID: 12021254

Deficiency of the membrane protein FAT/CD36 causes a marked defect in fatty acid uptake by various tissues and is genetically linked to insulin resistance in rats and humans. Here, we examined insulin responsiveness of CD36-/- mice. When fed a diet high in complex carbohydrates and low (5%) in fat, these animals cleared glucose faster than the wild-type.

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Accession: 003701646

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