EurekaMag
+ Translate
+ Most Popular
Investigations on the organic drift in North Swedish streams
Limitations of Using Microsoft Excel Version 2016 (MS Excel 2016) for Statistical Analysis for Medical Research
Phloem necrosis of coffee in Surinam
Anatomy of Mystus seenghala IV Nervous system
Integrated farming system for gardenland conditions of Coimbatore district - an over view
Tetrapleure (Tetrapleura tetraptera), an unknown African medicinal and spice plant
The origin and phylogenetic significance of the trochophoran larvae 2. evolutionary significance of the larvae of coelomate worms and mollusks
Comparison of rice bran and maize bran as feeds for growing and fattening pigs
Enterobacter amnigenus. An unusual human pathogen
Influence of Seriboost foliar application on leaf yield and leaf protein content in mulberry (Morus spp.), in relation to silkworm cocoon production
The identity of the lipstick mold of cultivated mushrooms agaricus bisporus
Advantages and disadvantages of bordeaux mixture and of lime-sulphur used on apples in the growing season
'Pan-sukh' disease of Rice in the Central Provinces
Geological age of the Ptilophyllum flora; a critical reassessment
Study of vitellogenesis in birds; physiological phases & role of folliculin in vitellogenesis
Evaluation of WCT coconut and Komadan coconut
Therapy for acne with saccharomyces boulardii
Evidence for Late Cretaceous N-S dextral shear in the west-central crystalline core, North Cascades, Washington
'Rajeshwari' - a high-yielding white seeded variety of sesame for Andhra Pradesh
Manufacture of Ricotta cheese from whey fortified with skim milk powder using different acidulants
Occurrence of Eutrichophilus mexicanus (Rudow, 1866) and Eutrichophilus lobatus (Ewing, 1936) (Phthiraptera: Trichodectidae) on Sphiggurus villosus (Cuvier, 1825) (Rodentia: Erethizontidae) in Rio de
Factors affecting fruitfulness in durian (Durio zibethinus Murr.). I. Flowering and pollination
Bronchial cuff pressure change caused by left-sided double-lumen endobronchial tube displacement
Some Biological Applications of Organometallic Compounds
The composition of pampas-grass (Cortaderia argentea.)

Defective Hyphal induction of a Candida albicans phosphatidylinositol 3-phosphate 5-kinase null mutant on solid media does not lead to decreased virulence


Defective Hyphal induction of a Candida albicans phosphatidylinositol 3-phosphate 5-kinase null mutant on solid media does not lead to decreased virulence



Infection and Immunity 70(8): 4462-4470



ISSN/ISBN: 0019-9567

PMID: 12117957

DOI: 10.1128/iai.70.8.4462-4470.2002

A phosphatidylinositol 3-phosphate 5-kinase gene (CaFAB1) of the most important human pathogenic yeast, Candida albicans, was cloned and sequenced. An open reading frame was detected which encodes a 2369-amino-acid protein with a calculated molecular mass of 268 kDa and a relative isoelectric point of 6.76. This protein exhibits 38% overall amino acid sequence identity with Saccharomyces cerevisiae Fab1p. We localized the CaFAB1 gene on chromosome R.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 003701647

Download citation: RISBibTeXText

Related references

Candida albicans glutathione reductase downregulates Efg1-mediated cyclic AMP/protein kinase A pathway and leads to defective hyphal growth and virulence upon decreased cellular methylglyoxal content accompanied by activating alcohol dehydrogenase and glycolytic enzymes. Biochimica et Biophysica Acta. General Subjects 1861(4): 772-788, 2017

Candida albicans ENO1 null mutants exhibit altered drug susceptibility, hyphal formation, and virulence. Journal of Microbiology 51(3): 345-351, 2013

Virulence and hyphal formation of Candida albicans require the Ste20p-like protein kinase CaCla4p. Current Biology: Cb 7(8): 539-546, 1997

Generation and functional in vivo characterization of a lipid kinase defective phosphatidylinositol 3-kinase Vps34p of Candida albicans. Microbiology 151(Pt 1): 81-89, 2005

Induction of hyphal form of Candida albicans in vitro by two culture media. Zhonghua Pifuke Zazhi 38(8): 501-502, 2005

Crk1, a novel Cdc2-related protein kinase, is required for hyphal development and virulence in Candida albicans. Molecular and Cellular Biology 20(23): 8696-8708, 2000

Roles of three histidine kinase genes in hyphal development and virulence of the pathogenic fungus Candida albicans. Journal of Bacteriology 181(23): 7243-7247, 1999

Derepressed hyphal growth and reduced virulence in a VH1 family-related protein phosphatase mutant of the human pathogen Candida albicans. Molecular Biology of the Cell 8(12): 2539-2551, 1997

The Candida albicans phosphatase Inp51p interacts with the EH domain protein Irs4p, regulates phosphatidylinositol-4,5-bisphosphate levels and influences hyphal formation, the cell integrity pathway and virulence. Microbiology 154(Pt 11): 3296-3308, 2008

A phosphatidylinositol 3-kinase of Candida albicans influences adhesion, filamentous growth and virulence. Microbiology 146: 2755-2764, 2000

Reduced expression of the hyphal-independent Candida albicans proteinase genes SAP1 and SAP3 in the efg1 mutant is associated with attenuated virulence during infection of oral epithelium. Journal of Medical Microbiology 52(Pt 8): 623-632, 2003

Hyphal growth in Candida albicans does not require induction of hyphal-specific gene expression. Molecular Biology of the Cell 26(6): 1174-1187, 2015

Phosphatidylinositol-4-phosphate 5-kinase activity is stimulated during temperature-induced morphogenesis in Candida albicans. Microbiology 148(Pt 6): 1737-1746, 2002

Accumulation of 14-methyl sterols and defective hyphal growth in Candida albicans. Journal of Medical and Veterinary Mycology: Bi-Monthly Publication of the International Society for Human and Animal Mycology 24(4): 327-336, 1986

Candida albicans hyphal formation and virulence: is there a clearly defined role?. Trends in Microbiology 6(3): 92-94, 1998