+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Deletion of the Aspergillus fumigatus gene encoding the Ras-related protein RhbA reduces virulence in a model of Invasive pulmonary aspergillosis



Deletion of the Aspergillus fumigatus gene encoding the Ras-related protein RhbA reduces virulence in a model of Invasive pulmonary aspergillosis



Infection and Immunity 71(5): 2819-2826



Aspergillus fumigatus is the predominant mold pathogen in patients who lack functional innate immunity. The A. fumigatus rhbA gene was first identified as a transcript that was upregulated when the organism was grown in the presence of mammalian cells. To gain insight into the function of rhbA in the growth and pathogenesis of A. fumigatus, we constructed a strain that lacks a functional rhbA gene.

(PDF emailed within 0-6 h: $19.90)

Accession: 003702284

Download citation: RISBibTeXText

PMID: 12704156

DOI: 10.1128/IAI.71.5.2819-2826.2003


Related references

Deletion of the Aspergillus fumigatus lysine biosynthesis gene lysF encoding homoaconitase leads to attenuated virulence in a low-dose mouse infection model of invasive aspergillosis. Archives of Microbiology 181(5): 378-383, 2004

Variation in virulence of Aspergillus fumigatus strains in a murine model of invasive pulmonary aspergillosis. Journal of Medical Microbiology 45(3): 186-191, 1996

Virulence of Aspergillus fumigatus double mutants lacking restriction and an alkaline protease in a low-dose model of invasive pulmonary aspergillosis. Infection and Immunity 62(12): 5247-5254, 1994

Virulence of Aspergillus fumigatus Double Mutants Lacking Restrictocin and an Alkaline Protease in a Low-Dose Model of Invasive Pulmonary Aspergillosis. Infection & Immunity 62(12): 5247-5254, 1994

Interstrain variability in the virulence of Aspergillus fumigatus and Aspergillus terreus in a Toll-deficient Drosophila fly model of invasive aspergillosis. Medical Mycology 48(2): 310-317, 2010

Disruption of the Aspergillus fumigatus gene encoding nucleolar protein CgrA impairs thermotolerant growth and reduces virulence. Infection and Immunity 72(8): 4731-4740, 2004

The alkaline protease of Aspergillus fumigatus is not a virulence determinant in two murine models of invasive pulmonary aspergillosis. Infection and Immunity 61(5): 1650-1656, 1993

Characteristics of culture-positive invasive pulmonary aspergillosis in patients with hematologic diseases: Comparison between Aspergillus fumigatus and non-fumigatus Aspergillus species. Medicine 96(49): E8841-E8841, 2017

The role of the Aspergillus fumigatus areA gene in invasive pulmonary aspergillosis. Molecular & General Genetics 258(5): 553-557, 1998

In vivo virulence of laboratory-selected azole-resistant Aspergillus fumigatus in a murine pulmonary aspergillosis model. Abstracts of the Interscience Conference on Antimicrobial Agents & Chemotherapy 41: 390-391, 2001

APX001 Pharmacokinetic/Pharmacodynamic Target Determination against Aspergillus fumigatus in an in vivo Model of Invasive Pulmonary Aspergillosis. Antimicrobial Agents and ChemoTherapy 2019, 2019

Combination of voriconazole and anidulafungin for treatment of triazole-resistant aspergillus fumigatus in an in vitro model of invasive pulmonary aspergillosis. Antimicrobial Agents and ChemoTherapy 56(10): 5180-5185, 2013

Molecular cloning and characterization of Aspergillus fumigatus gene encoding a protein involved in allergic bronchopulmonary aspergillosis. Journal of Allergy & Clinical Immunology 103(1 PART 2): S30, 1999

Detection of Aspergillus fumigatus in a rat model of invasive pulmonary aspergillosis by real-time nucleic acid sequence-based amplification. Journal of Clinical Microbiology 48(4): 1378-1383, 2010

Pathogenesis of Aspergillus fumigatus and the kinetics of galactomannan in an in vitro model of early invasive pulmonary aspergillosis: implications for antifungal therapy. Journal of Infectious Diseases 195(3): 455-466, 2007