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Design and analysis of post-fusion 6-helix bundle of heptad repeat regions from Newcastle disease virus F protein


Design and analysis of post-fusion 6-helix bundle of heptad repeat regions from Newcastle disease virus F protein



Protein Engineering 16(5): 373-379



ISSN/ISBN: 0269-2139

PMID: 12826729

DOI: 10.1093/protein/gzg041

Fusion of paramyxovirus to the cell involves receptor binding of the HN glycoprotein and a number of conformational changes of F glycoprotein. The F protein is expressed as a homotrimer on the virus surface. In the present model, there are at least three conformations of F protein, i.e. native form, pre-hairpin intermediate and the post-fusion state. In the post-fusion state, the two highly conserved heptad repeat (HR) regions of F protein form a stable 6-helix coiled-coil bundle.

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Accession: 003703590

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Related references

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