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Detection of pleiotropic or closely linked QTL in a granddaughter design


Detection of pleiotropic or closely linked QTL in a granddaughter design



Proceedings of the 7th World Congress on Genetics Applied to Livestock Production, Montpellier, France, August, 2002 Session 21: 1-4



This paper describes a method to determine pleiotropic effects of a quantitative trait locus (QTL) in a granddaughter design. The method is based on results from single trait analyses for different traits. The covariance between contrasts for different traits in single trait regression analysis is computed. A pleiotropic QTL results in a covariance between contrasts that deviates from the expected covariance under the null hypothesis that there is no QTL.

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