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Development and optimisation of a method for the extraction of benzimidazoles from animal liver using supercritical carbon dioxide


Development and optimisation of a method for the extraction of benzimidazoles from animal liver using supercritical carbon dioxide



Analytica Chimica Acta 483(1/2): 313-324



ISSN/ISBN: 0003-2670

DOI: 10.1016/s0003-2670(02)01532-5

A multi-residue supercritical fluid extraction (SFE) method has been developed for extraction of 10 benzimidazole drug residues from animal liver. The method may be applicable also to some other benzimidazoles, but recovery was not quantitative. An oven dried sample-hydromatrix mixture was packed into an extraction vessel and rehydrated with water (1 ml). The sample was extracted at 80 degrees C using 60 litre unmodified supercritical carbon dioxide (690 bar).

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Accession: 003708188

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