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Development of monoclonal antibodies to domoic acid for the detection of domoic acid in blue mussel (Mytilus edulis) tissue by ELISA

Kania, M.; Hock, B.

Analytical Letters 35(5): 855-868

2002

ISSN/ISBN: 0003-2719
DOI: 10.1081/al-120004074
Accession: 003709752
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Monoclonal antibodies were developed against domoic acid (DA), an algal toxin produced by the diatom Pseudonitzschia pungens. Three murine monoclonal antibodies, 4D1D, 9B10D, and 7D6C, were obtained from hybridoma clones. They were derived by fusion of mouse myeloma cells with mouse immune spleen cells derived from animals immunized with domoic acid-KLH conjugate. The hybridoma cell line 4D1D was adjusted to serum free medium.

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Related References

Madhyastha, M.S.; Novaczek, I.; Ablett, R.F.; Johnson, G.; Nijjar, M.S.; Sims, D.E. 1991: In vitro study of domoic acid uptake by digestive gland tissue of blue mussel mytilus edulis l Aquatic Toxicology (Amsterdam) 20(1-2): 73-82
Madhyastha, MS.; Novaczek, I.; Ablett, RF.; Johnson, G.; Nijjar, MS.; Sims, DE. 1991: In vitro study of domoic acid uptake by digestive gland tissue of blue mussel (Mytilus edulis) Aquatic Toxicology (Amsterdam): 201-2: 73-81
Grimmelt, B.; Nijjar, M.S.; Brown, J.; Macnair, N.; Wagner, S.; Johnson, G.R.; Amend, J.F. 1990: Relationship between domoic acid levels in the blue mussel (Mytilus Edulis) and toxocity in mice Toxicon (Oxford) 28(5): 501-508
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