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Development of transgenic rabbits with ribozyme directed to bovine leukemia virus rex/tax mRNA


Development of transgenic rabbits with ribozyme directed to bovine leukemia virus rex/tax mRNA



Bulletin of the Veterinary Institute in Puawy 46(2): 197-203



New Zealand White female rabbits were used as ova donors (n=80) or recipients of zygotes (n=57). A DNA construct, containing ribozyme directed to bovine leukaemia virus rex/tax messenger RNA, was microinjected into 1184 zygotes; 1100 of these were transferred to the recipients. 98 rabbits were born and 39 potentially transgenic animals were screened for the presence of the ribozyme sequence.

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