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Developmental defects and male sterility in mice lacking the ubiquitin-like DNA repair gene mHR23B


Developmental defects and male sterility in mice lacking the ubiquitin-like DNA repair gene mHR23B



Molecular and Cellular Biology 22(4): 1233-1245



ISSN/ISBN: 0270-7306

PMID: 11809813

DOI: 10.1128/mcb.22.4.1233-1245.2002

mHR23B encodes one of the two mammalian homologues of Saccharomyces cerevisiae RAD23, a ubiquitin-like fusion protein involved in nucleotide excision repair (NER). Part of mHR23B is complexed with the XPC protein, and this heterodimer functions as the main damage detector and initiator of global genome NER. While XPC defects exist in humans and mice, mutations for mHR23A and mHR23B are not known. Here, we present a mouse model for mHR23B.

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Accession: 003710486

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